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Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy
Background: We aimed to measure and correlate inner retinal layer (IRL) thickness and macular sensitivity by optical coherence tomography (OCT) and by microperimetry, respectively, in type 1 diabetes mellitus patients (DM1) without diabetic retinopathy (DR). Methods: Fifty-one DM1 patients and 81 ag...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830999/ https://www.ncbi.nlm.nih.gov/pubmed/33467213 http://dx.doi.org/10.3390/diagnostics11010136 |
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author | Orduna-Hospital, Elvira Otero-Rodríguez, Judit Perdices, Lorena Sánchez-Cano, Ana Boned-Murillo, Ana Acha, Javier Pinilla, Isabel |
author_facet | Orduna-Hospital, Elvira Otero-Rodríguez, Judit Perdices, Lorena Sánchez-Cano, Ana Boned-Murillo, Ana Acha, Javier Pinilla, Isabel |
author_sort | Orduna-Hospital, Elvira |
collection | PubMed |
description | Background: We aimed to measure and correlate inner retinal layer (IRL) thickness and macular sensitivity by optical coherence tomography (OCT) and by microperimetry, respectively, in type 1 diabetes mellitus patients (DM1) without diabetic retinopathy (DR). Methods: Fifty-one DM1 patients and 81 age-matched healthy subjects underwent measurement of the axial length (AL), retinal thickness in the macular ETDRS areas by swept source (SS)-OCT and macular sensitivity by microperimeter. Results: The total retinal and IRL thicknesses were thicker in the DM1 group (p < 0.05) in practically all ETDRS areas, and they had a generalized decrease in sensitivity (p < 0.05) in 9 areas between both groups. There was a significant negative correlation between retinal sensitivity and age in all areas and in visual acuity (VA) in 5 out of the 9 areas for DM1 patients. Only a mild negative correlation was observed between retinal sensitivity in the 5° nasal inner (5NI) area and in IRL thickness in the temporal inner (TI) area (−0.309 with p = 0.029) in the DM1 group. Conclusion: Aging and disease evolution in DM1 patients without DR signs generate a decrease in retinal sensitivity. There was a direct relationship between retinal sensitivity and macular thickness in the DM1 group. |
format | Online Article Text |
id | pubmed-7830999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78309992021-01-26 Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy Orduna-Hospital, Elvira Otero-Rodríguez, Judit Perdices, Lorena Sánchez-Cano, Ana Boned-Murillo, Ana Acha, Javier Pinilla, Isabel Diagnostics (Basel) Article Background: We aimed to measure and correlate inner retinal layer (IRL) thickness and macular sensitivity by optical coherence tomography (OCT) and by microperimetry, respectively, in type 1 diabetes mellitus patients (DM1) without diabetic retinopathy (DR). Methods: Fifty-one DM1 patients and 81 age-matched healthy subjects underwent measurement of the axial length (AL), retinal thickness in the macular ETDRS areas by swept source (SS)-OCT and macular sensitivity by microperimeter. Results: The total retinal and IRL thicknesses were thicker in the DM1 group (p < 0.05) in practically all ETDRS areas, and they had a generalized decrease in sensitivity (p < 0.05) in 9 areas between both groups. There was a significant negative correlation between retinal sensitivity and age in all areas and in visual acuity (VA) in 5 out of the 9 areas for DM1 patients. Only a mild negative correlation was observed between retinal sensitivity in the 5° nasal inner (5NI) area and in IRL thickness in the temporal inner (TI) area (−0.309 with p = 0.029) in the DM1 group. Conclusion: Aging and disease evolution in DM1 patients without DR signs generate a decrease in retinal sensitivity. There was a direct relationship between retinal sensitivity and macular thickness in the DM1 group. MDPI 2021-01-16 /pmc/articles/PMC7830999/ /pubmed/33467213 http://dx.doi.org/10.3390/diagnostics11010136 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Orduna-Hospital, Elvira Otero-Rodríguez, Judit Perdices, Lorena Sánchez-Cano, Ana Boned-Murillo, Ana Acha, Javier Pinilla, Isabel Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy |
title | Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy |
title_full | Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy |
title_fullStr | Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy |
title_full_unstemmed | Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy |
title_short | Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy |
title_sort | microperimetry and optical coherence tomography changes in type-1 diabetes mellitus without retinopathy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830999/ https://www.ncbi.nlm.nih.gov/pubmed/33467213 http://dx.doi.org/10.3390/diagnostics11010136 |
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