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Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy

Background: We aimed to measure and correlate inner retinal layer (IRL) thickness and macular sensitivity by optical coherence tomography (OCT) and by microperimetry, respectively, in type 1 diabetes mellitus patients (DM1) without diabetic retinopathy (DR). Methods: Fifty-one DM1 patients and 81 ag...

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Autores principales: Orduna-Hospital, Elvira, Otero-Rodríguez, Judit, Perdices, Lorena, Sánchez-Cano, Ana, Boned-Murillo, Ana, Acha, Javier, Pinilla, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830999/
https://www.ncbi.nlm.nih.gov/pubmed/33467213
http://dx.doi.org/10.3390/diagnostics11010136
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author Orduna-Hospital, Elvira
Otero-Rodríguez, Judit
Perdices, Lorena
Sánchez-Cano, Ana
Boned-Murillo, Ana
Acha, Javier
Pinilla, Isabel
author_facet Orduna-Hospital, Elvira
Otero-Rodríguez, Judit
Perdices, Lorena
Sánchez-Cano, Ana
Boned-Murillo, Ana
Acha, Javier
Pinilla, Isabel
author_sort Orduna-Hospital, Elvira
collection PubMed
description Background: We aimed to measure and correlate inner retinal layer (IRL) thickness and macular sensitivity by optical coherence tomography (OCT) and by microperimetry, respectively, in type 1 diabetes mellitus patients (DM1) without diabetic retinopathy (DR). Methods: Fifty-one DM1 patients and 81 age-matched healthy subjects underwent measurement of the axial length (AL), retinal thickness in the macular ETDRS areas by swept source (SS)-OCT and macular sensitivity by microperimeter. Results: The total retinal and IRL thicknesses were thicker in the DM1 group (p < 0.05) in practically all ETDRS areas, and they had a generalized decrease in sensitivity (p < 0.05) in 9 areas between both groups. There was a significant negative correlation between retinal sensitivity and age in all areas and in visual acuity (VA) in 5 out of the 9 areas for DM1 patients. Only a mild negative correlation was observed between retinal sensitivity in the 5° nasal inner (5NI) area and in IRL thickness in the temporal inner (TI) area (−0.309 with p = 0.029) in the DM1 group. Conclusion: Aging and disease evolution in DM1 patients without DR signs generate a decrease in retinal sensitivity. There was a direct relationship between retinal sensitivity and macular thickness in the DM1 group.
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spelling pubmed-78309992021-01-26 Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy Orduna-Hospital, Elvira Otero-Rodríguez, Judit Perdices, Lorena Sánchez-Cano, Ana Boned-Murillo, Ana Acha, Javier Pinilla, Isabel Diagnostics (Basel) Article Background: We aimed to measure and correlate inner retinal layer (IRL) thickness and macular sensitivity by optical coherence tomography (OCT) and by microperimetry, respectively, in type 1 diabetes mellitus patients (DM1) without diabetic retinopathy (DR). Methods: Fifty-one DM1 patients and 81 age-matched healthy subjects underwent measurement of the axial length (AL), retinal thickness in the macular ETDRS areas by swept source (SS)-OCT and macular sensitivity by microperimeter. Results: The total retinal and IRL thicknesses were thicker in the DM1 group (p < 0.05) in practically all ETDRS areas, and they had a generalized decrease in sensitivity (p < 0.05) in 9 areas between both groups. There was a significant negative correlation between retinal sensitivity and age in all areas and in visual acuity (VA) in 5 out of the 9 areas for DM1 patients. Only a mild negative correlation was observed between retinal sensitivity in the 5° nasal inner (5NI) area and in IRL thickness in the temporal inner (TI) area (−0.309 with p = 0.029) in the DM1 group. Conclusion: Aging and disease evolution in DM1 patients without DR signs generate a decrease in retinal sensitivity. There was a direct relationship between retinal sensitivity and macular thickness in the DM1 group. MDPI 2021-01-16 /pmc/articles/PMC7830999/ /pubmed/33467213 http://dx.doi.org/10.3390/diagnostics11010136 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Orduna-Hospital, Elvira
Otero-Rodríguez, Judit
Perdices, Lorena
Sánchez-Cano, Ana
Boned-Murillo, Ana
Acha, Javier
Pinilla, Isabel
Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy
title Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy
title_full Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy
title_fullStr Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy
title_full_unstemmed Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy
title_short Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy
title_sort microperimetry and optical coherence tomography changes in type-1 diabetes mellitus without retinopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830999/
https://www.ncbi.nlm.nih.gov/pubmed/33467213
http://dx.doi.org/10.3390/diagnostics11010136
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