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Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling
Here we describe the effects of a controlled, 30 min, high-intensity cycling test on blood rheology and the metabolic profiles of red blood cells (RBCs) and plasma from well-trained males. RBCs demonstrated decreased deformability and trended toward increased generation of microparticles after the t...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831009/ https://www.ncbi.nlm.nih.gov/pubmed/33477427 http://dx.doi.org/10.3390/ijms22020896 |
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author | Nemkov, Travis Skinner, Sarah C. Nader, Elie Stefanoni, Davide Robert, Mélanie Cendali, Francesca Stauffer, Emeric Cibiel, Agnes Boisson, Camille Connes, Philippe D’Alessandro, Angelo |
author_facet | Nemkov, Travis Skinner, Sarah C. Nader, Elie Stefanoni, Davide Robert, Mélanie Cendali, Francesca Stauffer, Emeric Cibiel, Agnes Boisson, Camille Connes, Philippe D’Alessandro, Angelo |
author_sort | Nemkov, Travis |
collection | PubMed |
description | Here we describe the effects of a controlled, 30 min, high-intensity cycling test on blood rheology and the metabolic profiles of red blood cells (RBCs) and plasma from well-trained males. RBCs demonstrated decreased deformability and trended toward increased generation of microparticles after the test. Meanwhile, metabolomics and lipidomics highlighted oxidative stress and activation of membrane lipid remodeling mechanisms in order to cope with altered properties of circulation resulting from physical exertion during the cycling test. Of note, intermediates from coenzyme A (CoA) synthesis for conjugation to fatty acyl chains, in parallel with reversible conversion of carnitine and acylcarnitines, emerged as metabolites that significantly correlate with RBC deformability and the generation of microparticles during exercise. Taken together, we propose that RBC membrane remodeling and repair plays an active role in the physiologic response to exercise by altering RBC properties. |
format | Online Article Text |
id | pubmed-7831009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78310092021-01-26 Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling Nemkov, Travis Skinner, Sarah C. Nader, Elie Stefanoni, Davide Robert, Mélanie Cendali, Francesca Stauffer, Emeric Cibiel, Agnes Boisson, Camille Connes, Philippe D’Alessandro, Angelo Int J Mol Sci Article Here we describe the effects of a controlled, 30 min, high-intensity cycling test on blood rheology and the metabolic profiles of red blood cells (RBCs) and plasma from well-trained males. RBCs demonstrated decreased deformability and trended toward increased generation of microparticles after the test. Meanwhile, metabolomics and lipidomics highlighted oxidative stress and activation of membrane lipid remodeling mechanisms in order to cope with altered properties of circulation resulting from physical exertion during the cycling test. Of note, intermediates from coenzyme A (CoA) synthesis for conjugation to fatty acyl chains, in parallel with reversible conversion of carnitine and acylcarnitines, emerged as metabolites that significantly correlate with RBC deformability and the generation of microparticles during exercise. Taken together, we propose that RBC membrane remodeling and repair plays an active role in the physiologic response to exercise by altering RBC properties. MDPI 2021-01-18 /pmc/articles/PMC7831009/ /pubmed/33477427 http://dx.doi.org/10.3390/ijms22020896 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nemkov, Travis Skinner, Sarah C. Nader, Elie Stefanoni, Davide Robert, Mélanie Cendali, Francesca Stauffer, Emeric Cibiel, Agnes Boisson, Camille Connes, Philippe D’Alessandro, Angelo Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling |
title | Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling |
title_full | Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling |
title_fullStr | Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling |
title_full_unstemmed | Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling |
title_short | Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling |
title_sort | acute cycling exercise induces changes in red blood cell deformability and membrane lipid remodeling |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831009/ https://www.ncbi.nlm.nih.gov/pubmed/33477427 http://dx.doi.org/10.3390/ijms22020896 |
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