Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans

In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we dis...

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Detalles Bibliográficos
Autores principales: Cagigi, Alberto, Loré, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831080/
https://www.ncbi.nlm.nih.gov/pubmed/33477534
http://dx.doi.org/10.3390/vaccines9010061
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author Cagigi, Alberto
Loré, Karin
author_facet Cagigi, Alberto
Loré, Karin
author_sort Cagigi, Alberto
collection PubMed
description In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we discuss in more detail the recent SARS-CoV-2 mRNA vaccine trials in humans.
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spelling pubmed-78310802021-01-26 Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans Cagigi, Alberto Loré, Karin Vaccines (Basel) Review In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we discuss in more detail the recent SARS-CoV-2 mRNA vaccine trials in humans. MDPI 2021-01-18 /pmc/articles/PMC7831080/ /pubmed/33477534 http://dx.doi.org/10.3390/vaccines9010061 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cagigi, Alberto
Loré, Karin
Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans
title Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans
title_full Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans
title_fullStr Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans
title_full_unstemmed Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans
title_short Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans
title_sort immune responses induced by mrna vaccination in mice, monkeys and humans
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831080/
https://www.ncbi.nlm.nih.gov/pubmed/33477534
http://dx.doi.org/10.3390/vaccines9010061
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