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Risk factors for Graves' Orbitopathy in surgical patients—Results of a 10‐year retrospective study with review of the literature

INTRODUCTION: We investigated known (eg age, smoking, thyrotropin receptor autoantibody (TRAb)) and new risk factors (eg thyroid peroxidase autoantibodies (TPO‐Ab), thyroid size, or BMI) for Graves' disease (GD) and Graves' orbitopathy (GO), especially in combination with each other, to de...

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Autores principales: Tabriz, Navid, Gruben, Arved, Uslar, Verena, Weyhe, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831207/
https://www.ncbi.nlm.nih.gov/pubmed/33532627
http://dx.doi.org/10.1002/edm2.210
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author Tabriz, Navid
Gruben, Arved
Uslar, Verena
Weyhe, Dirk
author_facet Tabriz, Navid
Gruben, Arved
Uslar, Verena
Weyhe, Dirk
author_sort Tabriz, Navid
collection PubMed
description INTRODUCTION: We investigated known (eg age, smoking, thyrotropin receptor autoantibody (TRAb)) and new risk factors (eg thyroid peroxidase autoantibodies (TPO‐Ab), thyroid size, or BMI) for Graves' disease (GD) and Graves' orbitopathy (GO), especially in combination with each other, to determine which factors play the most important role in the development of GO. METHODS: From 2008 to 2018, n = 500 patients with GD were included in this retrospective single‐centre case‐control study. N = 231 (46%) had a GO and n = 269 (54%) showed no GO. Differences in risk factors were determined by Mann‐Whitney U and chi‐square test. Combined influences of factors were examined by multivariable logistic regression. RESULTS: Age at first diagnosis of GD (OR = 1.043, p < .006), smoking status (OR = 2.64, p < .026) and TRAb (OR = 1.046, p < .01) had a significant impact on GO. The factors gender, TPO‐Ab titre, BMI, TSH titre, T3 and T4 were not significant. CONCLUSION: As it has been shown in univariate analyses, smoking, age and TRAb levels have a negative impact on the onset and course of GD and GO. Via multivariable regression, we could additionally show that smoking is the most important factor out of those analysed. TRAb might be a helpful surrogate parameter in the assessment of the progress of GO and therefore might be one factor in the decision‐making process for potential early operative surgery. With regard to the hitherto unclear role of BMI, thyroid size and TPO‐Ab in the course of GO, this study could not find any clinically relevant influence.
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spelling pubmed-78312072021-02-01 Risk factors for Graves' Orbitopathy in surgical patients—Results of a 10‐year retrospective study with review of the literature Tabriz, Navid Gruben, Arved Uslar, Verena Weyhe, Dirk Endocrinol Diabetes Metab Original Research Articles INTRODUCTION: We investigated known (eg age, smoking, thyrotropin receptor autoantibody (TRAb)) and new risk factors (eg thyroid peroxidase autoantibodies (TPO‐Ab), thyroid size, or BMI) for Graves' disease (GD) and Graves' orbitopathy (GO), especially in combination with each other, to determine which factors play the most important role in the development of GO. METHODS: From 2008 to 2018, n = 500 patients with GD were included in this retrospective single‐centre case‐control study. N = 231 (46%) had a GO and n = 269 (54%) showed no GO. Differences in risk factors were determined by Mann‐Whitney U and chi‐square test. Combined influences of factors were examined by multivariable logistic regression. RESULTS: Age at first diagnosis of GD (OR = 1.043, p < .006), smoking status (OR = 2.64, p < .026) and TRAb (OR = 1.046, p < .01) had a significant impact on GO. The factors gender, TPO‐Ab titre, BMI, TSH titre, T3 and T4 were not significant. CONCLUSION: As it has been shown in univariate analyses, smoking, age and TRAb levels have a negative impact on the onset and course of GD and GO. Via multivariable regression, we could additionally show that smoking is the most important factor out of those analysed. TRAb might be a helpful surrogate parameter in the assessment of the progress of GO and therefore might be one factor in the decision‐making process for potential early operative surgery. With regard to the hitherto unclear role of BMI, thyroid size and TPO‐Ab in the course of GO, this study could not find any clinically relevant influence. John Wiley and Sons Inc. 2020-12-04 /pmc/articles/PMC7831207/ /pubmed/33532627 http://dx.doi.org/10.1002/edm2.210 Text en © 2020 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Articles
Tabriz, Navid
Gruben, Arved
Uslar, Verena
Weyhe, Dirk
Risk factors for Graves' Orbitopathy in surgical patients—Results of a 10‐year retrospective study with review of the literature
title Risk factors for Graves' Orbitopathy in surgical patients—Results of a 10‐year retrospective study with review of the literature
title_full Risk factors for Graves' Orbitopathy in surgical patients—Results of a 10‐year retrospective study with review of the literature
title_fullStr Risk factors for Graves' Orbitopathy in surgical patients—Results of a 10‐year retrospective study with review of the literature
title_full_unstemmed Risk factors for Graves' Orbitopathy in surgical patients—Results of a 10‐year retrospective study with review of the literature
title_short Risk factors for Graves' Orbitopathy in surgical patients—Results of a 10‐year retrospective study with review of the literature
title_sort risk factors for graves' orbitopathy in surgical patients—results of a 10‐year retrospective study with review of the literature
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831207/
https://www.ncbi.nlm.nih.gov/pubmed/33532627
http://dx.doi.org/10.1002/edm2.210
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