Cargando…

CAR T cells in solid tumors: challenges and opportunities

BACKGROUND: CARs are simulated receptors containing an extracellular single-chain variable fragment (scFv), a transmembrane domain, as well as an intracellular region of immunoreceptor tyrosine-based activation motifs (ITAMs) in association with a co-stimulatory signal. MAIN BODY: Chimeric antigen r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marofi, Faroogh, Motavalli, Roza, Safonov, Vladimir A., Thangavelu, Lakshmi, Yumashev, Alexei Valerievich, Alexander, Markov, Shomali, Navid, Chartrand, Max Stanley, Pathak, Yashwant, Jarahian, Mostafa, Izadi, Sepideh, Hassanzadeh, Ali, Shirafkan, Naghmeh, Tahmasebi, Safa, Khiavi, Farhad Motavalli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831265/ https://www.ncbi.nlm.nih.gov/pubmed/33494834 http://dx.doi.org/10.1186/s13287-020-02128-1

Ejemplares similares

Any closer to successful therapy of multiple myeloma? CAR-T cell is a good reason for optimism
por: Marofi, Faroogh, et al.
Publicado: (2021)

Correction to: Any closer to successful therapy of multiple myeloma? CAR-T cell is a good reason for optimism
por: Marofi, Faroogh, et al.
Publicado: (2021)

Renaissance of armored immune effector cells, CAR-NK cells, brings the higher hope for successful cancer therapy
por: Marofi, Faroogh, et al.
Publicado: (2021)

CAR-engineered NK cells; a promising therapeutic option for treatment of hematological malignancies
por: Marofi, Faroogh, et al.
Publicado: (2021)

A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine
por: Moghadasi, Soudeh, et al.
Publicado: (2021)

A Deep Insight Into CAR-T Cell Therapy in Non-Hodgkin Lymphoma: Application, Opportunities, and Future Directions
por: Marofi, Faroogh, et al.
Publicado: (2021)

Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders
por: Markov, Alexander, et al.
Publicado: (2021)

CAR‐NK cell in cancer immunotherapy; A promising frontier
por: Marofi, Faroogh, et al.
Publicado: (2021)

Hurdles to breakthrough in CAR T cell therapy of solid tumors
por: Marofi, Faroogh, et al.
Publicado: (2022)

Novel CAR T therapy is a ray of hope in the treatment of seriously ill AML patients
por: Marofi, Faroogh, et al.
Publicado: (2021)

The Role of Janus Kinase/STAT3 Pathway in Hematologic Malignancies With an Emphasis on Epigenetics
por: Zeinalzadeh, Elham, et al.
Publicado: (2021)

A deep insight into CRISPR/Cas9 application in CAR-T cell-based tumor immunotherapies
por: Razeghian, Ehsan, et al.
Publicado: (2021)

CAR-NK Cell: A New Paradigm in Tumor Immunotherapy
por: Marofi, Faroogh, et al.
Publicado: (2021)

Mesenchymal Stem/Stromal Cell-Based Delivery: A Rapidly Evolving Strategy for Cancer Therapy
por: Hassanzadeh, Ali, et al.
Publicado: (2021)

Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities
por: Hassanzadeh, Ali, et al.
Publicado: (2021)

Dysregulation of Survivin-Targeting microRNAs in Autoimmune Diseases: New Perspectives for Novel Therapies
por: Shomali, Navid, et al.
Publicado: (2022)

A Dual-Type L2 11-88 Peptide from HPV Types 16/18 Formulated in Montanide ISA 720 Induced Strong and Balanced Th1/Th2 Immune Responses, Associated with High Titers of Broad Spectrum Cross-Reactive Antibodies in Vaccinated Mice
por: Motavalli Khiavi, Farhad, et al.
Publicado: (2018)

Biological causes of immunogenic cancer cell death (ICD) and anti-tumor therapy; Combination of Oncolytic virus-based immunotherapy and CAR T-cell therapy for ICD induction
por: Mardi, Amirhossein, et al.
Publicado: (2022)

Shining the light on clinical application of mesenchymal stem cell therapy in autoimmune diseases
por: Jasim, Saade Abdalkareem, et al.
Publicado: (2022)

Immunization of mice by a multimeric L2-based linear epitope (17-36) from HPV type 16/18 induced cross reactive neutralizing antibodies
por: Khiavi, Farhad Motavalli, et al.
Publicado: (2017)

Cloning and Embryo Splitting in Mammalians: Brief History, Methods, and Achievements
por: Rahbaran, Mohaddeseh, et al.
Publicado: (2021)

A comprehensive review about immune responses and exhaustion during coronavirus disease (COVID-19)
por: Mohammed, Rebar N., et al.
Publicado: (2022)

Correction to: A comprehensive review about immune responses and exhaustion during coronavirus disease (COVID-19)
por: Mohammed, Rebar N., et al.
Publicado: (2022)

Harnessing TRAIL-Induced Apoptosis Pathway for Cancer Immunotherapy and Associated Challenges
por: Razeghian, Ehsan, et al.
Publicado: (2021)

Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons
por: Naimi, Adel, et al.
Publicado: (2022)

Re-Expression of Poly/Oligo-Sialylated Adhesion Molecules on the Surface of Tumor Cells Disrupts Their Interaction with Immune-Effector Cells and Contributes to Pathophysiological Immune Escape
por: Jarahian, Mostafa, et al.
Publicado: (2021)

MicroRNAs and JAK/STAT3 signaling: A new promising therapeutic axis in blood cancers
por: Sajjadi-Dokht, Mehdi, et al.
Publicado: (2021)

CAR-modified immune cells as a rapidly evolving approach in the context of cancer immunotherapies
por: Faeq, Mohammed Hikmat, et al.
Publicado: (2023)

Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor (CAR) for tumor immunotherapy; recent progress
por: Budi, Hendrik Setia, et al.
Publicado: (2022)

Mesenchymal stem cells and cancer therapy: insights into targeting the tumour vasculature
por: Aravindhan, Surendar, et al.
Publicado: (2021)

Matrix metalloproteinases are involved in the development of neurological complications in patients with Coronavirus disease 2019
por: Mohammadhosayni, Mina, et al.
Publicado: (2021)

Healthcare information systems: the cognitive challenge
por: Lintern, Gavan, et al.
Publicado: (2018)

Complexity in simulation-based education: exploring the role of hindsight bias
por: Motavalli, Al, et al.
Publicado: (2016)

A Retrofit Theory to Prevent Fatigue Crack Initiation in Aging Riveted Bridges Using Carbon Fiber-Reinforced Polymer Materials
por: Ghafoori, Elyas, et al.
Publicado: (2016)

Up‐regulation of KISS1 as a novel target of Let‐7i in melanoma serves as a potential suppressor of migration and proliferation in vitro
por: Alkafaji, Haider A., et al.
Publicado: (2021)

Epigenetic mechanisms shape the underlining expression regulatory mechanisms of the STAT3 in multiple sclerosis disease
por: Hosseini, Arezoo, et al.
Publicado: (2020)

Mesenchymal Stem/Stromal Cells as a Vehicle for Cytokine Delivery: An Emerging Approach for Tumor Immunotherapy
por: Razeghian, Ehsan, et al.
Publicado: (2021)

Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol
por: Nakhaei, Pooria, et al.
Publicado: (2021)

Nanocurcumin improves Treg cell responses in patients with mild and severe SARS-CoV2
por: Tahmasebi, Safa, et al.
Publicado: (2021)

Correction: A comprehensive review about immune responses and exhaustion during coronavirus disease (COVID-19)
por: Mohammed, Rebar N., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_to2lvpnleicndh351uh229ikvk