TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism

This review summarizes important information on the ectoenzyme tissue-nonspecific alkaline phosphatase (TNAP) and gives a brief insight into the symptoms, diagnostics, and treatment of the rare disease Hypophosphatasia (HPP), which is resulting from mutations in the TNAP encoding ALPL gene. We empha...

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Detalles Bibliográficos
Autores principales: Graser, Stephanie, Liedtke, Daniel, Jakob, Franz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831495/
https://www.ncbi.nlm.nih.gov/pubmed/33477631
http://dx.doi.org/10.3390/ijms22020919
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author Graser, Stephanie
Liedtke, Daniel
Jakob, Franz
author_facet Graser, Stephanie
Liedtke, Daniel
Jakob, Franz
author_sort Graser, Stephanie
collection PubMed
description This review summarizes important information on the ectoenzyme tissue-nonspecific alkaline phosphatase (TNAP) and gives a brief insight into the symptoms, diagnostics, and treatment of the rare disease Hypophosphatasia (HPP), which is resulting from mutations in the TNAP encoding ALPL gene. We emphasize the role of TNAP beyond its well-known contribution to mineralization processes. Therefore, above all, the impact of the enzyme on central molecular processes in the nervous system and on inflammation is presented here.
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spelling pubmed-78314952021-01-26 TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism Graser, Stephanie Liedtke, Daniel Jakob, Franz Int J Mol Sci Review This review summarizes important information on the ectoenzyme tissue-nonspecific alkaline phosphatase (TNAP) and gives a brief insight into the symptoms, diagnostics, and treatment of the rare disease Hypophosphatasia (HPP), which is resulting from mutations in the TNAP encoding ALPL gene. We emphasize the role of TNAP beyond its well-known contribution to mineralization processes. Therefore, above all, the impact of the enzyme on central molecular processes in the nervous system and on inflammation is presented here. MDPI 2021-01-18 /pmc/articles/PMC7831495/ /pubmed/33477631 http://dx.doi.org/10.3390/ijms22020919 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Graser, Stephanie
Liedtke, Daniel
Jakob, Franz
TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism
title TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism
title_full TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism
title_fullStr TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism
title_full_unstemmed TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism
title_short TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism
title_sort tnap as a new player in chronic inflammatory conditions and metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831495/
https://www.ncbi.nlm.nih.gov/pubmed/33477631
http://dx.doi.org/10.3390/ijms22020919
work_keys_str_mv AT graserstephanie tnapasanewplayerinchronicinflammatoryconditionsandmetabolism
AT liedtkedaniel tnapasanewplayerinchronicinflammatoryconditionsandmetabolism
AT jakobfranz tnapasanewplayerinchronicinflammatoryconditionsandmetabolism

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