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Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins
Nucleic acid-binding proteins are traditionally divided into two categories: With the ability to bind DNA or RNA. In the light of new knowledge, such categorizing should be overcome because a large proportion of proteins can bind both DNA and RNA. Another even more important features of nucleic acid...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831508/ https://www.ncbi.nlm.nih.gov/pubmed/33477647 http://dx.doi.org/10.3390/ijms22020922 |
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author | Bartas, Martin Červeň, Jiří Guziurová, Simona Slychko, Kristyna Pečinka, Petr |
author_facet | Bartas, Martin Červeň, Jiří Guziurová, Simona Slychko, Kristyna Pečinka, Petr |
author_sort | Bartas, Martin |
collection | PubMed |
description | Nucleic acid-binding proteins are traditionally divided into two categories: With the ability to bind DNA or RNA. In the light of new knowledge, such categorizing should be overcome because a large proportion of proteins can bind both DNA and RNA. Another even more important features of nucleic acid-binding proteins are so-called sequence or structure specificities. Proteins able to bind nucleic acids in a sequence-specific manner usually contain one or more of the well-defined structural motifs (zinc-fingers, leucine zipper, helix-turn-helix, or helix-loop-helix). In contrast, many proteins do not recognize nucleic acid sequence but rather local DNA or RNA structures (G-quadruplexes, i-motifs, triplexes, cruciforms, left-handed DNA/RNA form, and others). Finally, there are also proteins recognizing both sequence and local structural properties of nucleic acids (e.g., famous tumor suppressor p53). In this mini-review, we aim to summarize current knowledge about the amino acid composition of various types of nucleic acid-binding proteins with a special focus on significant enrichment and/or depletion in each category. |
format | Online Article Text |
id | pubmed-7831508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78315082021-01-26 Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins Bartas, Martin Červeň, Jiří Guziurová, Simona Slychko, Kristyna Pečinka, Petr Int J Mol Sci Review Nucleic acid-binding proteins are traditionally divided into two categories: With the ability to bind DNA or RNA. In the light of new knowledge, such categorizing should be overcome because a large proportion of proteins can bind both DNA and RNA. Another even more important features of nucleic acid-binding proteins are so-called sequence or structure specificities. Proteins able to bind nucleic acids in a sequence-specific manner usually contain one or more of the well-defined structural motifs (zinc-fingers, leucine zipper, helix-turn-helix, or helix-loop-helix). In contrast, many proteins do not recognize nucleic acid sequence but rather local DNA or RNA structures (G-quadruplexes, i-motifs, triplexes, cruciforms, left-handed DNA/RNA form, and others). Finally, there are also proteins recognizing both sequence and local structural properties of nucleic acids (e.g., famous tumor suppressor p53). In this mini-review, we aim to summarize current knowledge about the amino acid composition of various types of nucleic acid-binding proteins with a special focus on significant enrichment and/or depletion in each category. MDPI 2021-01-18 /pmc/articles/PMC7831508/ /pubmed/33477647 http://dx.doi.org/10.3390/ijms22020922 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bartas, Martin Červeň, Jiří Guziurová, Simona Slychko, Kristyna Pečinka, Petr Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins |
title | Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins |
title_full | Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins |
title_fullStr | Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins |
title_full_unstemmed | Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins |
title_short | Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins |
title_sort | amino acid composition in various types of nucleic acid-binding proteins |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831508/ https://www.ncbi.nlm.nih.gov/pubmed/33477647 http://dx.doi.org/10.3390/ijms22020922 |
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