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Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins

Nucleic acid-binding proteins are traditionally divided into two categories: With the ability to bind DNA or RNA. In the light of new knowledge, such categorizing should be overcome because a large proportion of proteins can bind both DNA and RNA. Another even more important features of nucleic acid...

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Autores principales: Bartas, Martin, Červeň, Jiří, Guziurová, Simona, Slychko, Kristyna, Pečinka, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831508/
https://www.ncbi.nlm.nih.gov/pubmed/33477647
http://dx.doi.org/10.3390/ijms22020922
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author Bartas, Martin
Červeň, Jiří
Guziurová, Simona
Slychko, Kristyna
Pečinka, Petr
author_facet Bartas, Martin
Červeň, Jiří
Guziurová, Simona
Slychko, Kristyna
Pečinka, Petr
author_sort Bartas, Martin
collection PubMed
description Nucleic acid-binding proteins are traditionally divided into two categories: With the ability to bind DNA or RNA. In the light of new knowledge, such categorizing should be overcome because a large proportion of proteins can bind both DNA and RNA. Another even more important features of nucleic acid-binding proteins are so-called sequence or structure specificities. Proteins able to bind nucleic acids in a sequence-specific manner usually contain one or more of the well-defined structural motifs (zinc-fingers, leucine zipper, helix-turn-helix, or helix-loop-helix). In contrast, many proteins do not recognize nucleic acid sequence but rather local DNA or RNA structures (G-quadruplexes, i-motifs, triplexes, cruciforms, left-handed DNA/RNA form, and others). Finally, there are also proteins recognizing both sequence and local structural properties of nucleic acids (e.g., famous tumor suppressor p53). In this mini-review, we aim to summarize current knowledge about the amino acid composition of various types of nucleic acid-binding proteins with a special focus on significant enrichment and/or depletion in each category.
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spelling pubmed-78315082021-01-26 Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins Bartas, Martin Červeň, Jiří Guziurová, Simona Slychko, Kristyna Pečinka, Petr Int J Mol Sci Review Nucleic acid-binding proteins are traditionally divided into two categories: With the ability to bind DNA or RNA. In the light of new knowledge, such categorizing should be overcome because a large proportion of proteins can bind both DNA and RNA. Another even more important features of nucleic acid-binding proteins are so-called sequence or structure specificities. Proteins able to bind nucleic acids in a sequence-specific manner usually contain one or more of the well-defined structural motifs (zinc-fingers, leucine zipper, helix-turn-helix, or helix-loop-helix). In contrast, many proteins do not recognize nucleic acid sequence but rather local DNA or RNA structures (G-quadruplexes, i-motifs, triplexes, cruciforms, left-handed DNA/RNA form, and others). Finally, there are also proteins recognizing both sequence and local structural properties of nucleic acids (e.g., famous tumor suppressor p53). In this mini-review, we aim to summarize current knowledge about the amino acid composition of various types of nucleic acid-binding proteins with a special focus on significant enrichment and/or depletion in each category. MDPI 2021-01-18 /pmc/articles/PMC7831508/ /pubmed/33477647 http://dx.doi.org/10.3390/ijms22020922 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bartas, Martin
Červeň, Jiří
Guziurová, Simona
Slychko, Kristyna
Pečinka, Petr
Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins
title Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins
title_full Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins
title_fullStr Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins
title_full_unstemmed Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins
title_short Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins
title_sort amino acid composition in various types of nucleic acid-binding proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831508/
https://www.ncbi.nlm.nih.gov/pubmed/33477647
http://dx.doi.org/10.3390/ijms22020922
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