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Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies

Access to renal transplantation guarantees a substantial improvement in the clinical condition and quality of life (QoL) for end-stage renal disease (ESRD) patients. In recent years, a greater number of older patients starting renal replacement therapies (RRT) have shown the long-term impact of cons...

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Autores principales: Losappio, Vincenzo, Infante, Barbara, Leo, Serena, Troise, Dario, Calvaruso, Martina, Vitale, Piercarla, Renzi, Stefania, Stallone, Giovanni, Castellano, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831904/
https://www.ncbi.nlm.nih.gov/pubmed/33477671
http://dx.doi.org/10.3390/nu13010267
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author Losappio, Vincenzo
Infante, Barbara
Leo, Serena
Troise, Dario
Calvaruso, Martina
Vitale, Piercarla
Renzi, Stefania
Stallone, Giovanni
Castellano, Giuseppe
author_facet Losappio, Vincenzo
Infante, Barbara
Leo, Serena
Troise, Dario
Calvaruso, Martina
Vitale, Piercarla
Renzi, Stefania
Stallone, Giovanni
Castellano, Giuseppe
author_sort Losappio, Vincenzo
collection PubMed
description Access to renal transplantation guarantees a substantial improvement in the clinical condition and quality of life (QoL) for end-stage renal disease (ESRD) patients. In recent years, a greater number of older patients starting renal replacement therapies (RRT) have shown the long-term impact of conservative therapies for advanced CKD and the consequences of the uremic milieu, with a frail clinical condition that impacts not only their survival but also limits their access to transplantation. This process, referred to as “inflammaging,” might be reversible with a tailored approach, such as RRT accompanied by specific nutritional support. In this review, we summarize the evidence demonstrating the presence of several proinflammatory substances in the Western diet (WD) and the positive effect of unprocessed food consumption and increased fruit and vegetable intake, suggesting a new approach to reduce inflammaging with the improvement of ESRD clinical status. We conclude that the Mediterranean diet (MD), because of its modulative effects on microbiota and its anti-inflammaging properties, may be a cornerstone in a more precise nutritional support for patients on the waiting list for kidney transplantation.
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spelling pubmed-78319042021-01-26 Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies Losappio, Vincenzo Infante, Barbara Leo, Serena Troise, Dario Calvaruso, Martina Vitale, Piercarla Renzi, Stefania Stallone, Giovanni Castellano, Giuseppe Nutrients Review Access to renal transplantation guarantees a substantial improvement in the clinical condition and quality of life (QoL) for end-stage renal disease (ESRD) patients. In recent years, a greater number of older patients starting renal replacement therapies (RRT) have shown the long-term impact of conservative therapies for advanced CKD and the consequences of the uremic milieu, with a frail clinical condition that impacts not only their survival but also limits their access to transplantation. This process, referred to as “inflammaging,” might be reversible with a tailored approach, such as RRT accompanied by specific nutritional support. In this review, we summarize the evidence demonstrating the presence of several proinflammatory substances in the Western diet (WD) and the positive effect of unprocessed food consumption and increased fruit and vegetable intake, suggesting a new approach to reduce inflammaging with the improvement of ESRD clinical status. We conclude that the Mediterranean diet (MD), because of its modulative effects on microbiota and its anti-inflammaging properties, may be a cornerstone in a more precise nutritional support for patients on the waiting list for kidney transplantation. MDPI 2021-01-18 /pmc/articles/PMC7831904/ /pubmed/33477671 http://dx.doi.org/10.3390/nu13010267 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Losappio, Vincenzo
Infante, Barbara
Leo, Serena
Troise, Dario
Calvaruso, Martina
Vitale, Piercarla
Renzi, Stefania
Stallone, Giovanni
Castellano, Giuseppe
Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies
title Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies
title_full Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies
title_fullStr Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies
title_full_unstemmed Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies
title_short Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies
title_sort nutrition-based management of inflammaging in ckd and renal replacement therapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831904/
https://www.ncbi.nlm.nih.gov/pubmed/33477671
http://dx.doi.org/10.3390/nu13010267
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