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Virtual Screening of Natural Compounds as Potential PI(3)K-AKT1 Signaling Pathway Inhibitors and Experimental Validation

A computational screening for natural compounds suitable to bind the AKT protein has been performed after the generation of a pharmacophore model based on the experimental structure of AKT1 complexed with IQO, a well-known inhibitor. The compounds resulted as being most suitable from the screening h...

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Detalles Bibliográficos
Autores principales:	Dotolo, Serena, Cervellera, Carmen, Russo, Maria, Russo, Gian Luigi, Facchiano, Angelo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831918/ https://www.ncbi.nlm.nih.gov/pubmed/33477701 http://dx.doi.org/10.3390/molecules26020492

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