Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction

HIV reverse transcriptases (RTs) convert viral genomic RNA into double-stranded DNA. During reverse transcription, polypurine tracts (PPTs) resilient to RNase H cleavage are used as primers for plus-strand DNA synthesis. Nonnucleoside RT inhibitors (NNRTIs) can interfere with the initiation of plus-...

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Detalles Bibliográficos
Autores principales: Álvarez, Mar, Sapena-Ventura, Enrique, Luczkowiak, Joanna, Martín-Alonso, Samara, Menéndez-Arias, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831940/
https://www.ncbi.nlm.nih.gov/pubmed/33477685
http://dx.doi.org/10.3390/v13010131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831940/
https://www.ncbi.nlm.nih.gov/pubmed/33477685
http://dx.doi.org/10.3390/v13010131

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