COVID-19: disease, or no disease? - that is the question. It’s the dose stupid!

The COVID-19 pandemic has raised many issues not the least of which is the reason for its high variability in consequences to the infected person. In this opinion letter, we advocate that the dose and presentation of the infecting virus is a major factor that affects whether the outcome is subclinic...

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Detalles Bibliográficos
Autores principales: Sehrawat, Sharvan, Rouse, Barry T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Institut Pasteur. Published by Elsevier Masson SAS. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832071/
https://www.ncbi.nlm.nih.gov/pubmed/33450356
http://dx.doi.org/10.1016/j.micinf.2021.104779
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author Sehrawat, Sharvan
Rouse, Barry T.
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Rouse, Barry T.
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description The COVID-19 pandemic has raised many issues not the least of which is the reason for its high variability in consequences to the infected person. In this opinion letter, we advocate that the dose and presentation of the infecting virus is a major factor that affects whether the outcome is subclinical, tissue damaging or even lethal following infection. We briefly describe the known effects of virus dose on the course COVID-19 and discuss practical maneuvers as well as largely untested procedures that can raise the threshold dose needed to break through barriers of resistance.
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spelling pubmed-78320712021-01-26 COVID-19: disease, or no disease? - that is the question. It’s the dose stupid! Sehrawat, Sharvan Rouse, Barry T. Microbes Infect Review The COVID-19 pandemic has raised many issues not the least of which is the reason for its high variability in consequences to the infected person. In this opinion letter, we advocate that the dose and presentation of the infecting virus is a major factor that affects whether the outcome is subclinical, tissue damaging or even lethal following infection. We briefly describe the known effects of virus dose on the course COVID-19 and discuss practical maneuvers as well as largely untested procedures that can raise the threshold dose needed to break through barriers of resistance. Institut Pasteur. Published by Elsevier Masson SAS. 2021 2021-01-12 /pmc/articles/PMC7832071/ /pubmed/33450356 http://dx.doi.org/10.1016/j.micinf.2021.104779 Text en © 2021 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Sehrawat, Sharvan
Rouse, Barry T.
COVID-19: disease, or no disease? - that is the question. It’s the dose stupid!
title COVID-19: disease, or no disease? - that is the question. It’s the dose stupid!
title_full COVID-19: disease, or no disease? - that is the question. It’s the dose stupid!
title_fullStr COVID-19: disease, or no disease? - that is the question. It’s the dose stupid!
title_full_unstemmed COVID-19: disease, or no disease? - that is the question. It’s the dose stupid!
title_short COVID-19: disease, or no disease? - that is the question. It’s the dose stupid!
title_sort covid-19: disease, or no disease? - that is the question. it’s the dose stupid!
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832071/
https://www.ncbi.nlm.nih.gov/pubmed/33450356
http://dx.doi.org/10.1016/j.micinf.2021.104779
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