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Point of view: Should COVID-19 patients be supplemented with vitamin D?
Using Hill's methodology for exploring causality, we aimed to determine in early May 2020 whether evidence supports vitamin D as a biological determinant of COVID-19 outcomes. Vitamin D is a secosteroid hormone theoretically able to reduce COVID-19 risk through regulation of (i) the renin-angio...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832241/ https://www.ncbi.nlm.nih.gov/pubmed/32972631 http://dx.doi.org/10.1016/j.maturitas.2020.06.003 |
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author | Annweiler, Cédric Cao, Zhijian Sabatier, Jean-Marc |
author_facet | Annweiler, Cédric Cao, Zhijian Sabatier, Jean-Marc |
author_sort | Annweiler, Cédric |
collection | PubMed |
description | Using Hill's methodology for exploring causality, we aimed to determine in early May 2020 whether evidence supports vitamin D as a biological determinant of COVID-19 outcomes. Vitamin D is a secosteroid hormone theoretically able to reduce COVID-19 risk through regulation of (i) the renin-angiotensin system, (ii) cellular innate and adaptive immunity, and (iii) physical barriers. Inverse associations were found between 25-hydroxyvitamin D concentrations and COVID-19 incidence and mortality. Randomized controlled trials testing vitamin D supplementation in the treatment of COVID-19 are in progress. Positive results in such studies would encourage the use of vitamin D supplements as an adjuvant treatment in COVID-19. |
format | Online Article Text |
id | pubmed-7832241 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78322412021-01-26 Point of view: Should COVID-19 patients be supplemented with vitamin D? Annweiler, Cédric Cao, Zhijian Sabatier, Jean-Marc Maturitas Article Using Hill's methodology for exploring causality, we aimed to determine in early May 2020 whether evidence supports vitamin D as a biological determinant of COVID-19 outcomes. Vitamin D is a secosteroid hormone theoretically able to reduce COVID-19 risk through regulation of (i) the renin-angiotensin system, (ii) cellular innate and adaptive immunity, and (iii) physical barriers. Inverse associations were found between 25-hydroxyvitamin D concentrations and COVID-19 incidence and mortality. Randomized controlled trials testing vitamin D supplementation in the treatment of COVID-19 are in progress. Positive results in such studies would encourage the use of vitamin D supplements as an adjuvant treatment in COVID-19. Elsevier B.V. 2020-10 2020-06-08 /pmc/articles/PMC7832241/ /pubmed/32972631 http://dx.doi.org/10.1016/j.maturitas.2020.06.003 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Annweiler, Cédric Cao, Zhijian Sabatier, Jean-Marc Point of view: Should COVID-19 patients be supplemented with vitamin D? |
title | Point of view: Should COVID-19 patients be supplemented with vitamin D? |
title_full | Point of view: Should COVID-19 patients be supplemented with vitamin D? |
title_fullStr | Point of view: Should COVID-19 patients be supplemented with vitamin D? |
title_full_unstemmed | Point of view: Should COVID-19 patients be supplemented with vitamin D? |
title_short | Point of view: Should COVID-19 patients be supplemented with vitamin D? |
title_sort | point of view: should covid-19 patients be supplemented with vitamin d? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832241/ https://www.ncbi.nlm.nih.gov/pubmed/32972631 http://dx.doi.org/10.1016/j.maturitas.2020.06.003 |
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