mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration

mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target “undruggable” diseases. Recent advancement...

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Detalles Bibliográficos
Autores principales: Chanda, Palas K., Sukhovershin, Roman, Cooke, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832270/
https://www.ncbi.nlm.nih.gov/pubmed/33477787
http://dx.doi.org/10.3390/cells10010187
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author Chanda, Palas K.
Sukhovershin, Roman
Cooke, John P.
author_facet Chanda, Palas K.
Sukhovershin, Roman
Cooke, John P.
author_sort Chanda, Palas K.
collection PubMed
description mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target “undruggable” diseases. Recent advancement in the field of RNA therapeutics have addressed the challenges inherent to this drug molecule and this approach is now being applied to several therapeutic modalities, from cancer immunotherapy to vaccine development. In this review, we discussed the use of mRNA for stem cell generation or enhancement for the purpose of cardiovascular regeneration.
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spelling pubmed-78322702021-01-26 mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration Chanda, Palas K. Sukhovershin, Roman Cooke, John P. Cells Review mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target “undruggable” diseases. Recent advancement in the field of RNA therapeutics have addressed the challenges inherent to this drug molecule and this approach is now being applied to several therapeutic modalities, from cancer immunotherapy to vaccine development. In this review, we discussed the use of mRNA for stem cell generation or enhancement for the purpose of cardiovascular regeneration. MDPI 2021-01-19 /pmc/articles/PMC7832270/ /pubmed/33477787 http://dx.doi.org/10.3390/cells10010187 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chanda, Palas K.
Sukhovershin, Roman
Cooke, John P.
mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration
title mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration
title_full mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration
title_fullStr mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration
title_full_unstemmed mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration
title_short mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration
title_sort mrna-enhanced cell therapy and cardiovascular regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832270/
https://www.ncbi.nlm.nih.gov/pubmed/33477787
http://dx.doi.org/10.3390/cells10010187
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