Cargando…

Inhibition of iNKT Cells by the HLA-G-ILT2 Checkpoint and Poor Stimulation by HLA-G-Expressing Tolerogenic DC

Invariant Natural Killer T (iNKT) cells are a small and distinct population of T cells crucial in immunomodulation. After activation by alpha-GalactosylCeramide (αGC), an exogenic glycolipid antigen, iNKT cells can rapidly release cytokines to enhance specific anti-tumor activity. Several human clin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Ching-Lien, Caumartin, Julien, Amodio, Giada, Anna, François, Loustau, Maria, Gregori, Silvia, Langlade-Demoyen, Pierre, LeMaoult, Joel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832389/ https://www.ncbi.nlm.nih.gov/pubmed/33505397 http://dx.doi.org/10.3389/fimmu.2020.608614

Ejemplares similares

First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G
por: Anna, François, et al.
Publicado: (2021)

HLA-G Neo-Expression on Tumors
por: Loustau, Maria, et al.
Publicado: (2020)

Soluble HLA-G and HLA-G Bearing Extracellular Vesicles Affect ILT-2 Positive and ILT-2 Negative CD8 T Cells Complementary
por: Schwich, Esther, et al.
Publicado: (2020)

Tolerogenic Function of Dimeric Forms of HLA-G Recombinant Proteins: A Comparative Study In Vivo
por: Favier, Benoit, et al.
Publicado: (2011)

Recombinant HLA-G as Tolerogenic Immunomodulant in Experimental Small Bowel Transplantation
por: von Websky, Martin W., et al.
Publicado: (2016)

Editorial: The Biological and Clinical Aspects of HLA-G
por: LeMaoult, Joel, et al.
Publicado: (2021)

HLA-G Expression on Blasts and Tolerogenic Cells in Patients Affected by Acute Myeloid Leukemia
por: Locafaro, Grazia, et al.
Publicado: (2014)

The Dual Role of HLA-G in Cancer
por: Rouas-Freiss, Nathalie, et al.
Publicado: (2014)

Editorial: The Biological and Clinical Aspects of HLA-G, Volume II
por: LeMaoult, Joel, et al.
Publicado: (2022)

Human tolerogenic DC-10: perspectives for clinical applications
por: Amodio, Giada, et al.
Publicado: (2012)

HLA-G/ILTs Targeted Solid Cancer Immunotherapy: Opportunities and Challenges
por: Lin, Aifen, et al.
Publicado: (2021)

Skin Immunity and Tolerance: Focus on Epidermal Keratinocytes Expressing HLA-G
por: Mestrallet, Guillaume, et al.
Publicado: (2021)

HLA-G Genotype/Expression/Disease Association Studies: Success, Hurdles, and Perspectives
por: Amodio, Giada, et al.
Publicado: (2020)

HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy
por: Rebmann, Vera, et al.
Publicado: (2014)

HLA-G expressing DC-10 and CD4(+) T cells accumulate in human decidua during pregnancy
por: Amodio, Giada, et al.
Publicado: (2013)

HLA-G Orchestrates the Early Interaction of Human Trophoblasts with the Maternal Niche
por: Gregori, Silvia, et al.
Publicado: (2015)

Peripheral HLA-G/ILT-2 immune checkpoint axis in acute and convalescent COVID-19 patients
por: Rohn, Hana, et al.
Publicado: (2023)

Prognostic Significance of Immune Checkpoints HLA-G/ILT-2/4 and PD-L1 in Colorectal Cancer
por: Chen, Qiong-Yuan, et al.
Publicado: (2021)

Human Hepatocytes and Differentiated Adult-Derived Human Liver Stem/Progenitor Cells Display In Vitro Immunosuppressive Properties Mediated, at Least in Part, through the Nonclassical HLA Class I Molecule HLA-G
por: Lombard, Catherine A., et al.
Publicado: (2019)

The immune-checkpoint HLA-G/ILT4 is involved in the regulation of VEGF expression in clear cell renal cell carcinoma
por: García, Marcela, et al.
Publicado: (2020)

Association of genetic variants in the 3′UTR of HLA-G with Recurrent Pregnancy Loss
por: Amodio, Giada, et al.
Publicado: (2016)

Novel landscape of HLA‐G isoforms expressed in clear cell renal cell carcinoma patients
por: Tronik‐Le Roux, Diana, et al.
Publicado: (2017)

Altered Frequency and Phenotype of HLA-G-Expressing DC-10 in Type 1 Diabetes Patients at Onset and in Subjects at Risk to Develop the Disease
por: Amodio, Giada, et al.
Publicado: (2021)

Effect of HLA-G5 Immune Checkpoint Molecule on the Expression of ILT-2, CD27, and CD38 in Splenic B cells
por: Rohn, Hana, et al.
Publicado: (2022)

Human Keratinocytes Inhibit CD4(+) T-Cell Proliferation through TGFB1 Secretion and Surface Expression of HLA-G1 and PD-L1 Immune Checkpoints
por: Mestrallet, Guillaume, et al.
Publicado: (2021)

Spatial distribution of IL4 controls iNKT cell-DC crosstalk in tumors
por: Wang, Lu, et al.
Publicado: (2019)

HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers
por: Li, Peilong, et al.
Publicado: (2021)

NKT10 cells: a novel iNKT cell subset
por: Wingender, Gerhard, et al.
Publicado: (2015)

Haplotypes of the HLA-G 3’ Untranslated Region Respond to Endogenous Factors of HLA-G+ and HLA-G- Cell Lines Differentially
por: Poras, Isabelle, et al.
Publicado: (2017)

Prediction of non-muscle-invasive bladder cancer recurrence by measurement of checkpoint HLAG’s receptor ILT2 on peripheral CD8(+) T cells
por: Desgrandchamps, Francois, et al.
Publicado: (2018)

iNKT and MAIT Cell Alterations in Diabetes
por: Magalhaes, Isabelle, et al.
Publicado: (2015)

The Role of Autophagy in iNKT Cell Development
por: Yang, Guan, et al.
Publicado: (2018)

Recent advances in iNKT cell development
por: Hogquist, Kristin, et al.
Publicado: (2020)

Editorial: HLA-G-Mediated Immune Tolerance: Past and New Outlooks
por: Gregori, Silvia
Publicado: (2016)

Elevated sHLA-G plasma levels post chemotherapy combined with ILT-2 rs10416697C allele status of the sHLA-G-related receptor predict poorest disease outcome in early triple-negative breast cancer patients
por: Hoffmann, Oliver, et al.
Publicado: (2023)

β-Catenin is required for the differentiation of iNKT2 and iNKT17 cells that augment IL-25-dependent lung inflammation
por: Berga-Bolaños, Rosa, et al.
Publicado: (2015)

Graphene oxide polarizes iNKT cells for production of TGFβ and attenuates inflammation in an iNKT cell-mediated sepsis model
por: Lee, Sung Won, et al.
Publicado: (2018)

Regeneration of invariant natural killer T (iNKT) cells: application of iPSC technology for iNKT cell-targeted tumor immunotherapy
por: Aoki, Takahiro, et al.
Publicado: (2023)

HLA-G UTR Haplotype Conservation in the Malian Population: Association with Soluble HLA-G
por: Carlini, Federico, et al.
Publicado: (2013)

The iNKT Cell–Macrophage Axis in Homeostasis and Disease
por: Cruz, Mariana S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vcosa0nk6dsalt6dib1pdq8sui