Nanobodies, the potent agents to detect and treat the Coronavirus infections: A systematic review

The newly emerged coronavirus (SARS-CoV-2) continues to infect humans, and no effective treatment has yet been found. Antibody therapy is one way to control infection caused by COVID-19. However, the use of classical antibodies raises complex issues. Heavy chain antibodies (HCAbs) are single-domain...

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Autores principales: Zare, Hamed, Aghamollaei, Hossein, Hosseindokht, Maryam, Heiat, Mohammad, Razei, Ali, Bakherad, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832525/
https://www.ncbi.nlm.nih.gov/pubmed/33358936
http://dx.doi.org/10.1016/j.mcp.2020.101692
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author Zare, Hamed
Aghamollaei, Hossein
Hosseindokht, Maryam
Heiat, Mohammad
Razei, Ali
Bakherad, Hamid
author_facet Zare, Hamed
Aghamollaei, Hossein
Hosseindokht, Maryam
Heiat, Mohammad
Razei, Ali
Bakherad, Hamid
author_sort Zare, Hamed
collection PubMed
description The newly emerged coronavirus (SARS-CoV-2) continues to infect humans, and no effective treatment has yet been found. Antibody therapy is one way to control infection caused by COVID-19. However, the use of classical antibodies raises complex issues. Heavy chain antibodies (HCAbs) are single-domain antibodies derived from the Camelidae family. The variable part of these antibodies (Nanobodies or VHH) has interesting properties such as small size, cost-effective production, and good tissue permeability, causing VHH to be regarded as an antiviral therapeutics. However, the small size of nanobodies may lead to low antigen binding affinity and rapid renal clearance. In this systematic review, the application of nanobodies in the treatment of COVID-19 infection and other similar infections (MERS and SARS) was reviewed.
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spelling pubmed-78325252021-01-26 Nanobodies, the potent agents to detect and treat the Coronavirus infections: A systematic review Zare, Hamed Aghamollaei, Hossein Hosseindokht, Maryam Heiat, Mohammad Razei, Ali Bakherad, Hamid Mol Cell Probes Review The newly emerged coronavirus (SARS-CoV-2) continues to infect humans, and no effective treatment has yet been found. Antibody therapy is one way to control infection caused by COVID-19. However, the use of classical antibodies raises complex issues. Heavy chain antibodies (HCAbs) are single-domain antibodies derived from the Camelidae family. The variable part of these antibodies (Nanobodies or VHH) has interesting properties such as small size, cost-effective production, and good tissue permeability, causing VHH to be regarded as an antiviral therapeutics. However, the small size of nanobodies may lead to low antigen binding affinity and rapid renal clearance. In this systematic review, the application of nanobodies in the treatment of COVID-19 infection and other similar infections (MERS and SARS) was reviewed. Published by Elsevier Ltd. 2021-02 2020-12-28 /pmc/articles/PMC7832525/ /pubmed/33358936 http://dx.doi.org/10.1016/j.mcp.2020.101692 Text en © 2020 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Zare, Hamed
Aghamollaei, Hossein
Hosseindokht, Maryam
Heiat, Mohammad
Razei, Ali
Bakherad, Hamid
Nanobodies, the potent agents to detect and treat the Coronavirus infections: A systematic review
title Nanobodies, the potent agents to detect and treat the Coronavirus infections: A systematic review
title_full Nanobodies, the potent agents to detect and treat the Coronavirus infections: A systematic review
title_fullStr Nanobodies, the potent agents to detect and treat the Coronavirus infections: A systematic review
title_full_unstemmed Nanobodies, the potent agents to detect and treat the Coronavirus infections: A systematic review
title_short Nanobodies, the potent agents to detect and treat the Coronavirus infections: A systematic review
title_sort nanobodies, the potent agents to detect and treat the coronavirus infections: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832525/
https://www.ncbi.nlm.nih.gov/pubmed/33358936
http://dx.doi.org/10.1016/j.mcp.2020.101692
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