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Unusual zwitterionic catalytic site of SARS–CoV-2 main protease revealed by neutron crystallography

The main protease (3CL M(pro)) from SARS–CoV-2, the etiological agent of COVID-19, is an essential enzyme for viral replication. 3CL M(pro) possesses an unusual catalytic dyad composed of Cys(145) and His(41) residues. A critical question in the field has been what the protonation states of the ioni...

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Detalles Bibliográficos
Autores principales:	Kneller, Daniel W., Phillips, Gwyndalyn, Weiss, Kevin L., Pant, Swati, Zhang, Qiu, O'Neill, Hugh M., Coates, Leighton, Kovalevsky, Andrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832724/ https://www.ncbi.nlm.nih.gov/pubmed/33060199 http://dx.doi.org/10.1074/jbc.AC120.016154

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