Persistent replication of SARS-CoV-2 in a severely immunocompromised patient treated with several courses of remdesivir

Microbiological response of SARS-CoV-2 to remdesivir in immunocompromised patients has not been evaluated. We present the case of a severely immunocompromised patient with persistent replication of SARS-CoV-2, who required different courses of remdesivir. Short courses of remdesivir might be insuffi...

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Autores principales: Camprubí, Daniel, Gaya, Anna, Marcos, Maria Angeles, Martí-Soler, Helena, Soriano, Alex, Mosquera, Maria del Mar, Oliver, Aina, Santos, Marta, Muñoz, Jose, García-Vidal, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832789/
https://www.ncbi.nlm.nih.gov/pubmed/33359065
http://dx.doi.org/10.1016/j.ijid.2020.12.050
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author Camprubí, Daniel
Gaya, Anna
Marcos, Maria Angeles
Martí-Soler, Helena
Soriano, Alex
Mosquera, Maria del Mar
Oliver, Aina
Santos, Marta
Muñoz, Jose
García-Vidal, Carol
author_facet Camprubí, Daniel
Gaya, Anna
Marcos, Maria Angeles
Martí-Soler, Helena
Soriano, Alex
Mosquera, Maria del Mar
Oliver, Aina
Santos, Marta
Muñoz, Jose
García-Vidal, Carol
author_sort Camprubí, Daniel
collection PubMed
description Microbiological response of SARS-CoV-2 to remdesivir in immunocompromised patients has not been evaluated. We present the case of a severely immunocompromised patient with persistent replication of SARS-CoV-2, who required different courses of remdesivir. Short courses of remdesivir might be insufficient in immunocompromised patients due to prolonged viral clearance.
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spelling pubmed-78327892021-01-26 Persistent replication of SARS-CoV-2 in a severely immunocompromised patient treated with several courses of remdesivir Camprubí, Daniel Gaya, Anna Marcos, Maria Angeles Martí-Soler, Helena Soriano, Alex Mosquera, Maria del Mar Oliver, Aina Santos, Marta Muñoz, Jose García-Vidal, Carol Int J Infect Dis Case Report Microbiological response of SARS-CoV-2 to remdesivir in immunocompromised patients has not been evaluated. We present the case of a severely immunocompromised patient with persistent replication of SARS-CoV-2, who required different courses of remdesivir. Short courses of remdesivir might be insufficient in immunocompromised patients due to prolonged viral clearance. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-03 2020-12-21 /pmc/articles/PMC7832789/ /pubmed/33359065 http://dx.doi.org/10.1016/j.ijid.2020.12.050 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Camprubí, Daniel
Gaya, Anna
Marcos, Maria Angeles
Martí-Soler, Helena
Soriano, Alex
Mosquera, Maria del Mar
Oliver, Aina
Santos, Marta
Muñoz, Jose
García-Vidal, Carol
Persistent replication of SARS-CoV-2 in a severely immunocompromised patient treated with several courses of remdesivir
title Persistent replication of SARS-CoV-2 in a severely immunocompromised patient treated with several courses of remdesivir
title_full Persistent replication of SARS-CoV-2 in a severely immunocompromised patient treated with several courses of remdesivir
title_fullStr Persistent replication of SARS-CoV-2 in a severely immunocompromised patient treated with several courses of remdesivir
title_full_unstemmed Persistent replication of SARS-CoV-2 in a severely immunocompromised patient treated with several courses of remdesivir
title_short Persistent replication of SARS-CoV-2 in a severely immunocompromised patient treated with several courses of remdesivir
title_sort persistent replication of sars-cov-2 in a severely immunocompromised patient treated with several courses of remdesivir
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832789/
https://www.ncbi.nlm.nih.gov/pubmed/33359065
http://dx.doi.org/10.1016/j.ijid.2020.12.050
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