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Essential updates 2018/2019: Current topics in the surgical treatment of pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is highly malignant. While cancers in other organs have shown clear improvements in 5‐year survival, the 5‐year survival rate of pancreatic cancer is approximately 10%. Early relapse and metastasis are not uncommon, making it difficult to achieve an acceptable...

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Detalles Bibliográficos
Autores principales: Ishido, Keinosuke, Hakamada, Kenichi, Kimura, Norihisa, Miura, Takuya, Wakiya, Taiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832965/
https://www.ncbi.nlm.nih.gov/pubmed/33532676
http://dx.doi.org/10.1002/ags3.12379
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author Ishido, Keinosuke
Hakamada, Kenichi
Kimura, Norihisa
Miura, Takuya
Wakiya, Taiichi
author_facet Ishido, Keinosuke
Hakamada, Kenichi
Kimura, Norihisa
Miura, Takuya
Wakiya, Taiichi
author_sort Ishido, Keinosuke
collection PubMed
description Pancreatic ductal adenocarcinoma (PDAC) is highly malignant. While cancers in other organs have shown clear improvements in 5‐year survival, the 5‐year survival rate of pancreatic cancer is approximately 10%. Early relapse and metastasis are not uncommon, making it difficult to achieve an acceptable prognosis even after complete surgical resection of the pancreas. Studies have been performed on various treatments to improve the prognosis of PDAC, and multidisciplinary approaches including non‐surgical treatments have led to gradual improvement. In the present literature review, we have described the significance of anatomical and biological resectability criteria, the concept of R0 resection in surgical treatment, the feasibility of minimally invasive surgery, the remarkable development of perioperative chemotherapy, the effectiveness of conversion surgery for unresectable PDAC, and ongoing challenges in PDAC treatment. We also provide an essential update on these subjects by focusing on recent trends and topics.
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spelling pubmed-78329652021-02-01 Essential updates 2018/2019: Current topics in the surgical treatment of pancreatic ductal adenocarcinoma Ishido, Keinosuke Hakamada, Kenichi Kimura, Norihisa Miura, Takuya Wakiya, Taiichi Ann Gastroenterol Surg Review Articles Pancreatic ductal adenocarcinoma (PDAC) is highly malignant. While cancers in other organs have shown clear improvements in 5‐year survival, the 5‐year survival rate of pancreatic cancer is approximately 10%. Early relapse and metastasis are not uncommon, making it difficult to achieve an acceptable prognosis even after complete surgical resection of the pancreas. Studies have been performed on various treatments to improve the prognosis of PDAC, and multidisciplinary approaches including non‐surgical treatments have led to gradual improvement. In the present literature review, we have described the significance of anatomical and biological resectability criteria, the concept of R0 resection in surgical treatment, the feasibility of minimally invasive surgery, the remarkable development of perioperative chemotherapy, the effectiveness of conversion surgery for unresectable PDAC, and ongoing challenges in PDAC treatment. We also provide an essential update on these subjects by focusing on recent trends and topics. John Wiley and Sons Inc. 2020-08-09 /pmc/articles/PMC7832965/ /pubmed/33532676 http://dx.doi.org/10.1002/ags3.12379 Text en © 2020 The Authors. Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterology This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Ishido, Keinosuke
Hakamada, Kenichi
Kimura, Norihisa
Miura, Takuya
Wakiya, Taiichi
Essential updates 2018/2019: Current topics in the surgical treatment of pancreatic ductal adenocarcinoma
title Essential updates 2018/2019: Current topics in the surgical treatment of pancreatic ductal adenocarcinoma
title_full Essential updates 2018/2019: Current topics in the surgical treatment of pancreatic ductal adenocarcinoma
title_fullStr Essential updates 2018/2019: Current topics in the surgical treatment of pancreatic ductal adenocarcinoma
title_full_unstemmed Essential updates 2018/2019: Current topics in the surgical treatment of pancreatic ductal adenocarcinoma
title_short Essential updates 2018/2019: Current topics in the surgical treatment of pancreatic ductal adenocarcinoma
title_sort essential updates 2018/2019: current topics in the surgical treatment of pancreatic ductal adenocarcinoma
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832965/
https://www.ncbi.nlm.nih.gov/pubmed/33532676
http://dx.doi.org/10.1002/ags3.12379
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