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Fever: Could A Cardinal Sign of COVID-19 Infection Reduce Mortality?
With mortality rising from the COVID-19 pandemic, we may be overlooking a key aspect of the immunological response. Fever is a cardinal sign of this rampant infection; however, little attention has been paid towards how a fever may work in our favor in overcoming this disease. Three key aspects of p...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Southern Society for Clinical Investigation. Published by Elsevier Inc.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833112/ https://www.ncbi.nlm.nih.gov/pubmed/33781387 http://dx.doi.org/10.1016/j.amjms.2021.01.004 |
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author | Cann, Stephen A Hoption |
author_facet | Cann, Stephen A Hoption |
author_sort | Cann, Stephen A Hoption |
collection | PubMed |
description | With mortality rising from the COVID-19 pandemic, we may be overlooking a key aspect of the immunological response. Fever is a cardinal sign of this rampant infection; however, little attention has been paid towards how a fever may work in our favor in overcoming this disease. Three key aspects of patient care – fever, fluid, and food – can be harmonized to overcome COVID-19 infection. Both animal and human studies have demonstrated that fever suppression during viral infections, either through low ambient temperatures or antipyretic use, may increase morbidity and prolong the illness. As fever rises, so do antidiuretic hormone levels, leading to solute-free water retention – making conservative fluid management essential. Finally, fever inhibits gastrointestinal function as energy is reallocated to the immunological response, underscoring the need to work in concert with these physiological changes. An opportunity awaits to investigate this natural barrier to infection, let us not pass it by. |
format | Online Article Text |
id | pubmed-7833112 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Southern Society for Clinical Investigation. Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78331122021-01-26 Fever: Could A Cardinal Sign of COVID-19 Infection Reduce Mortality? Cann, Stephen A Hoption Am J Med Sci Review Article With mortality rising from the COVID-19 pandemic, we may be overlooking a key aspect of the immunological response. Fever is a cardinal sign of this rampant infection; however, little attention has been paid towards how a fever may work in our favor in overcoming this disease. Three key aspects of patient care – fever, fluid, and food – can be harmonized to overcome COVID-19 infection. Both animal and human studies have demonstrated that fever suppression during viral infections, either through low ambient temperatures or antipyretic use, may increase morbidity and prolong the illness. As fever rises, so do antidiuretic hormone levels, leading to solute-free water retention – making conservative fluid management essential. Finally, fever inhibits gastrointestinal function as energy is reallocated to the immunological response, underscoring the need to work in concert with these physiological changes. An opportunity awaits to investigate this natural barrier to infection, let us not pass it by. Southern Society for Clinical Investigation. Published by Elsevier Inc. 2021-04 2021-01-09 /pmc/articles/PMC7833112/ /pubmed/33781387 http://dx.doi.org/10.1016/j.amjms.2021.01.004 Text en © 2021 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Article Cann, Stephen A Hoption Fever: Could A Cardinal Sign of COVID-19 Infection Reduce Mortality? |
title | Fever: Could A Cardinal Sign of COVID-19 Infection Reduce Mortality? |
title_full | Fever: Could A Cardinal Sign of COVID-19 Infection Reduce Mortality? |
title_fullStr | Fever: Could A Cardinal Sign of COVID-19 Infection Reduce Mortality? |
title_full_unstemmed | Fever: Could A Cardinal Sign of COVID-19 Infection Reduce Mortality? |
title_short | Fever: Could A Cardinal Sign of COVID-19 Infection Reduce Mortality? |
title_sort | fever: could a cardinal sign of covid-19 infection reduce mortality? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833112/ https://www.ncbi.nlm.nih.gov/pubmed/33781387 http://dx.doi.org/10.1016/j.amjms.2021.01.004 |
work_keys_str_mv | AT cannstephenahoption fevercouldacardinalsignofcovid19infectionreducemortality |