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Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites

Mutations that increase the protein kinase activity of LRRK2 are one of the most common causes of familial Parkinson's disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif, impacting interaction with effectors. We describe and validate a new, multiplexed targeted m...

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Detalles Bibliográficos
Autores principales:	Nirujogi, Raja S., Tonelli, Francesca, Taylor, Matthew, Lis, Pawel, Zimprich, Alexander, Sammler, Esther, Alessi, Dario R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2021
Materias:	Signaling
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833208/ https://www.ncbi.nlm.nih.gov/pubmed/33367571 http://dx.doi.org/10.1042/BCJ20200930

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