Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site

Bifunctional 8-oxoguanine-DNA glycosylase (OGG1), a crucial DNA-repair enzyme, removes from DNA 8-oxo-7,8-dihydroguanine (8-oxoG) with following cleavage of the arising apurinic/apyrimidinic (AP) site. The major enzyme in eukaryotic cells that catalyzes the cleavage of AP sites is AP endonuclease 1...

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Detalles Bibliográficos
Autores principales: Lebedeva, Natalia A., Rechkunova, Nadejda I., Endutkin, Anton V., Lavrik, Olga I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833210/
https://www.ncbi.nlm.nih.gov/pubmed/33505969
http://dx.doi.org/10.3389/fcell.2020.617301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833210/
https://www.ncbi.nlm.nih.gov/pubmed/33505969
http://dx.doi.org/10.3389/fcell.2020.617301

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