Cargando…

T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics

HIV-1 strains harboring immune escape mutations can persist in circulation, but the impact of selection by multiple HLA alleles on population HIV-1 dynamics remains unclear. In Japan, HIV-1 Reverse Transcriptase codon 135 (RT135) is under strong immune pressure by HLA-B*51:01-restricted and HLA-B*52...

Descripción completa

Detalles Bibliográficos
Autores principales:	Akahoshi, Tomohiro, Gatanaga, Hiroyuki, Kuse, Nozomi, Chikata, Takayuki, Koyanagi, Madoka, Ishizuka, Naoki, Brumme, Chanson J., Murakoshi, Hayato, Brumme, Zabrina L., Oka, Shinichi, Takiguchi, Masafumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833229/ https://www.ncbi.nlm.nih.gov/pubmed/33370400 http://dx.doi.org/10.1371/journal.ppat.1009177

Ejemplares similares

Role of Escape Mutant-Specific T Cells in Suppression of HIV-1 Replication and Coevolution with HIV-1
por: Zhang, Yu, et al.
Publicado: (2020)

Impact of a single HLA-A*24:02-associated escape mutation on the detrimental effect of HLA-B*35:01 in HIV-1 control
por: Murakoshi, Hayato, et al.
Publicado: (2018)

Erratum to: Lack of a significant impact of Gag-Protease-mediated HIV-1 replication capacity on clinical parameters in treatment-naive Japanese individuals
por: Sakai, Keiko, et al.
Publicado: (2015)

CD8(+) T cells specific for conserved, cross-reactive Gag epitopes with strong ability to suppress HIV-1 replication
por: Murakoshi, Hayato, et al.
Publicado: (2018)

Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens
por: Zou, Chengcheng, et al.
Publicado: (2019)

Effect of Difference in Consensus Sequence between HIV-1 Subtype A/E and Subtype B Viruses on Elicitation of Gag-Specific CD8(+) T Cells and Accumulation of HLA-Associated Escape Mutations
por: Zhang, Yu, et al.
Publicado: (2021)

Immunological Control of HIV-1 Disease Progression by Rare Protective HLA Allele
por: Zhang, Yu, et al.
Publicado: (2022)

Lack of a significant impact of Gag-Protease-mediated HIV-1 replication capacity on clinical parameters in treatment-naive Japanese individuals
por: Sakai, Keiko, et al.
Publicado: (2015)

Collaboration of a Detrimental HLA-B*35:01 Allele with HLA-A*24:02 in Coevolution of HIV-1 with T Cells Leading to Poorer Clinical Outcomes
por: Kuse, Nozomi, et al.
Publicado: (2021)

Epitope-dependent effect of long-term cART on maintenance and recovery of HIV-1-specific CD8(+) T cells
por: Kuse, Nozomi, et al.
Publicado: (2023)

Critical effect of Pol escape mutations associated with detrimental allele HLA-C(∗)15:05 on clinical outcome in HIV-1 subtype A/E infection
por: Murakoshi, Hayato, et al.
Publicado: (2021)

Identification of Immunodominant HIV-1 Epitopes Presented by HLA-C*12:02, a Protective Allele, Using an Immunopeptidomics Approach
por: Chikata, Takayuki, et al.
Publicado: (2019)

Long-term memory CD8(+) T cells specific for SARS-CoV-2 in individuals who received the BNT162b2 mRNA vaccine
por: Kuse, Nozomi, et al.
Publicado: (2022)

The impact of HLA-Cw*12:02 on control of HIV-1 infection
por: Koyanagi, M, et al.
Publicado: (2012)

HIV-1 protective epitope-specific CD8(+) T cells in HIV-1-exposed seronegative individuals
por: Chikata, Takayuki, et al.
Publicado: (2023)

STING Ligand-Mediated Priming of Functional CD8(+) T Cells Specific for HIV-1-Protective Epitopes from Naive T Cells
por: Kuse, Nozomi, et al.
Publicado: (2021)

Impact of Micropolymorphism Outside the Peptide Binding Groove in the Clinically Relevant Allele HLA-C*14 on T Cell Responses in HIV-1 Infection
por: Chikata, Takayuki, et al.
Publicado: (2022)

Control of HIV-1 Replication by CD8(+) T Cells Specific for Two Novel Pol Protective Epitopes in HIV-1 Subtype A/E Infection
por: Nguyen, Hung The, et al.
Publicado: (2022)

Cross-clade CTL recognitions for clade B and A/E viruses in A/E virus-infected Japanese individuals
por: Watanabe, K, et al.
Publicado: (2012)

Identification of novel HIV-1-derived HLA-E-binding peptides
por: Hannoun, Zara, et al.
Publicado: (2018)

HLA-associated viral polymorphism in chronically HIV-1-infected Japanese cohort: analysis of four-digit HLA allele level
por: Chikata, T, et al.
Publicado: (2012)

P16-06. Control of HIV-1 by HIV-1 Pol-specific CD8+ T cells in chronically HIV-1-infected Japanese cohort
por: Murakoshi, H, et al.
Publicado: (2009)

Control of HIV-1 by multiple immunodominant HIV-1-specific CD8+ T cells in HIV-1-infected Japanese individuals
por: Murakoshi, H, et al.
Publicado: (2012)

Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag
por: Carlson, Jonathan M., et al.
Publicado: (2008)

Priming of HIV-1-specific CD8(+) T cells with strong functional properties from naïve T cells
por: Kuse, Nozomi, et al.
Publicado: (2019)

Different abilities of CTL specific for two HLA-A*24:02-restricted overlapping optimal epitopes to select same HIV-1 escape mutant virus
por: Sun, X, et al.
Publicado: (2012)

Concordance of HIV transmission risk factors elucidated using viral diversification rate and phylogenetic clustering
por: McLaughlin, Angela, et al.
Publicado: (2021)

Sociodemographic correlates of HIV drug resistance and access to drug resistance testing in British Columbia, Canada
por: Rocheleau, Genevieve, et al.
Publicado: (2017)

Detection of HIV transmission hotspots in British Columbia, Canada: A novel framework for the prioritization and allocation of treatment and prevention resources
por: McLaughlin, Angela, et al.
Publicado: (2019)

Rates and Correlates of Short Term Virologic Response among Treatment-Naïve HIV-Infected Children Initiating Antiretroviral Therapy in Ethiopia: A Multi-Center Prospective Cohort Study
por: Tadesse, Birkneh Tilahun, et al.
Publicado: (2019)

Proviral Turnover During Untreated HIV Infection Is Dynamic and Variable Between Hosts, Impacting Reservoir Composition on ART
por: Brooks, Kelsie, et al.
Publicado: (2021)

Tracking the culprit: HIV-1 evolution and immune selection revealed by single-genome amplification
por: Brumme, Zabrina L., et al.
Publicado: (2009)

HLA-Associated Immune Escape Pathways in HIV-1 Subtype B Gag, Pol and Nef Proteins
por: Brumme, Zabrina L., et al.
Publicado: (2009)

Longitudinal within-host evolution of HIV Nef-mediated CD4, HLA and SERINC5 downregulation activity: a case study
por: Sudderuddin, Hanwei, et al.
Publicado: (2020)

HIV proviral genetic diversity, compartmentalization and inferred dynamics in lung and blood during long-term suppressive antiretroviral therapy
por: Shahid, Aniqa, et al.
Publicado: (2022)

Characteristics and Outcomes of Initial Virologic Suppressors during Analytic Treatment Interruption in a Therapeutic HIV-1 gag Vaccine Trial
por: Li, Jonathan Z., et al.
Publicado: (2012)

Rapid Detection of SARS-CoV-2 Variants of Concern, Including B.1.1.28/P.1, British Columbia, Canada
por: Matic, Nancy, et al.
Publicado: (2021)

Inhibition of the TRIM24 bromodomain reactivates latent HIV-1
por: Horvath, Riley M., et al.
Publicado: (2023)

CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells
por: Horvath, Riley M., et al.
Publicado: (2023)

Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8(+) T Cells
por: Streeck, Hendrik, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_cd1hi12ahr3qe3fbqvnt1367ni