The growing complexity of COVID-19 drug and vaccine candidates: challenges and critical transitions

COVID-19 has nowadays affected almost all our societies and global health systems. The latest deadly pandemic has heavily influenced both life and livelihood worldwide. SARS-CoV-2 is the causative organism of COVID-19, that is spreading and infecting significantly higher compared to other coronaviru...

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Autores principales: Shariare, Mohammad Hossain, Parvez, Md. Anowar Khasru, Karikas, George A., Kazi, Mohsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833287/
https://www.ncbi.nlm.nih.gov/pubmed/33493917
http://dx.doi.org/10.1016/j.jiph.2020.12.009
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author Shariare, Mohammad Hossain
Parvez, Md. Anowar Khasru
Karikas, George A.
Kazi, Mohsin
author_facet Shariare, Mohammad Hossain
Parvez, Md. Anowar Khasru
Karikas, George A.
Kazi, Mohsin
author_sort Shariare, Mohammad Hossain
collection PubMed
description COVID-19 has nowadays affected almost all our societies and global health systems. The latest deadly pandemic has heavily influenced both life and livelihood worldwide. SARS-CoV-2 is the causative organism of COVID-19, that is spreading and infecting significantly higher compared to other coronavirus, due to its constant mutation characteristics. At present although several extensive clinical trials are ongoing, neither approved drug therapy nor any vaccine are available to safely fight SARS-CoV-2. However, a progressive race among numerous research groups to discover a radical cure for the COVID-19 is under way. This review aims to provide an updated insight of the current research, development and trials on repurposing existing drugs and preventive intervention for COVID-19, along with the related issues, complexities and challenges, especially after the observed high transmissibility lately.
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spelling pubmed-78332872021-01-26 The growing complexity of COVID-19 drug and vaccine candidates: challenges and critical transitions Shariare, Mohammad Hossain Parvez, Md. Anowar Khasru Karikas, George A. Kazi, Mohsin J Infect Public Health Article COVID-19 has nowadays affected almost all our societies and global health systems. The latest deadly pandemic has heavily influenced both life and livelihood worldwide. SARS-CoV-2 is the causative organism of COVID-19, that is spreading and infecting significantly higher compared to other coronavirus, due to its constant mutation characteristics. At present although several extensive clinical trials are ongoing, neither approved drug therapy nor any vaccine are available to safely fight SARS-CoV-2. However, a progressive race among numerous research groups to discover a radical cure for the COVID-19 is under way. This review aims to provide an updated insight of the current research, development and trials on repurposing existing drugs and preventive intervention for COVID-19, along with the related issues, complexities and challenges, especially after the observed high transmissibility lately. Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. 2021-02 2020-12-15 /pmc/articles/PMC7833287/ /pubmed/33493917 http://dx.doi.org/10.1016/j.jiph.2020.12.009 Text en © 2020 Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Shariare, Mohammad Hossain
Parvez, Md. Anowar Khasru
Karikas, George A.
Kazi, Mohsin
The growing complexity of COVID-19 drug and vaccine candidates: challenges and critical transitions
title The growing complexity of COVID-19 drug and vaccine candidates: challenges and critical transitions
title_full The growing complexity of COVID-19 drug and vaccine candidates: challenges and critical transitions
title_fullStr The growing complexity of COVID-19 drug and vaccine candidates: challenges and critical transitions
title_full_unstemmed The growing complexity of COVID-19 drug and vaccine candidates: challenges and critical transitions
title_short The growing complexity of COVID-19 drug and vaccine candidates: challenges and critical transitions
title_sort growing complexity of covid-19 drug and vaccine candidates: challenges and critical transitions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833287/
https://www.ncbi.nlm.nih.gov/pubmed/33493917
http://dx.doi.org/10.1016/j.jiph.2020.12.009
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