Pathogenesis of COVID-19 and the quality control of nucleic acid detection

The new coronavirus pneumonia (COVID-19) epidemic spread rapidly throughout the world. Considering the strong infectivity and clustering of COVID-19, early detection of infectious cases is of great significance to control the epidemic. Nucleic acid testing (NAT) plays an important role in rapid labo...

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Autores principales: Mao, Xiao-Dong, Li, Taiping, Xu, Zhirong, Liu, Kangsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833324/
https://www.ncbi.nlm.nih.gov/pubmed/33581843
http://dx.doi.org/10.1016/j.bbrc.2020.12.094
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author Mao, Xiao-Dong
Li, Taiping
Xu, Zhirong
Liu, Kangsheng
author_facet Mao, Xiao-Dong
Li, Taiping
Xu, Zhirong
Liu, Kangsheng
author_sort Mao, Xiao-Dong
collection PubMed
description The new coronavirus pneumonia (COVID-19) epidemic spread rapidly throughout the world. Considering the strong infectivity and clustering of COVID-19, early detection of infectious cases is of great significance to control the epidemic. Nucleic acid testing (NAT) plays an important role in rapid laboratory diagnosis, treatment assessment, epidemic prevention and control of COVID-19. However, since COVID-19 is caused by a new emerging virus and NAT for COVID-19 has not been clinically applied before, false negative results inconsistent with clinical diagnosis have appeared in clinical practice. Therefore, it is urgent to improve the sensitivity of NAT for COVID-19. This study aimed to summarize the current situation and prospect of NAT based on the latest findings on COVID-19 infection. Also, the quality control of sample collection was discussed. Hopefully, this study could help to improve the effectiveness of NAT for COVID-19.
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spelling pubmed-78333242021-01-26 Pathogenesis of COVID-19 and the quality control of nucleic acid detection Mao, Xiao-Dong Li, Taiping Xu, Zhirong Liu, Kangsheng Biochem Biophys Res Commun Article The new coronavirus pneumonia (COVID-19) epidemic spread rapidly throughout the world. Considering the strong infectivity and clustering of COVID-19, early detection of infectious cases is of great significance to control the epidemic. Nucleic acid testing (NAT) plays an important role in rapid laboratory diagnosis, treatment assessment, epidemic prevention and control of COVID-19. However, since COVID-19 is caused by a new emerging virus and NAT for COVID-19 has not been clinically applied before, false negative results inconsistent with clinical diagnosis have appeared in clinical practice. Therefore, it is urgent to improve the sensitivity of NAT for COVID-19. This study aimed to summarize the current situation and prospect of NAT based on the latest findings on COVID-19 infection. Also, the quality control of sample collection was discussed. Hopefully, this study could help to improve the effectiveness of NAT for COVID-19. Elsevier Inc. 2022-02-05 2021-01-01 /pmc/articles/PMC7833324/ /pubmed/33581843 http://dx.doi.org/10.1016/j.bbrc.2020.12.094 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mao, Xiao-Dong
Li, Taiping
Xu, Zhirong
Liu, Kangsheng
Pathogenesis of COVID-19 and the quality control of nucleic acid detection
title Pathogenesis of COVID-19 and the quality control of nucleic acid detection
title_full Pathogenesis of COVID-19 and the quality control of nucleic acid detection
title_fullStr Pathogenesis of COVID-19 and the quality control of nucleic acid detection
title_full_unstemmed Pathogenesis of COVID-19 and the quality control of nucleic acid detection
title_short Pathogenesis of COVID-19 and the quality control of nucleic acid detection
title_sort pathogenesis of covid-19 and the quality control of nucleic acid detection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833324/
https://www.ncbi.nlm.nih.gov/pubmed/33581843
http://dx.doi.org/10.1016/j.bbrc.2020.12.094
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