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Macrophages in Healing Wounds: Paradoxes and Paradigms

Macrophages are prominent cells in normally healing adult skin wounds, yet their exact functions and functional significance to healing outcomes remain enigmatic. Many functional attributes are ascribed to wound macrophages, including host defense and support of the proliferation of new tissue to re...

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Autores principales: DiPietro, Luisa A., Wilgus, Traci A., Koh, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833402/
https://www.ncbi.nlm.nih.gov/pubmed/33477945
http://dx.doi.org/10.3390/ijms22020950
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author DiPietro, Luisa A.
Wilgus, Traci A.
Koh, Timothy J.
author_facet DiPietro, Luisa A.
Wilgus, Traci A.
Koh, Timothy J.
author_sort DiPietro, Luisa A.
collection PubMed
description Macrophages are prominent cells in normally healing adult skin wounds, yet their exact functions and functional significance to healing outcomes remain enigmatic. Many functional attributes are ascribed to wound macrophages, including host defense and support of the proliferation of new tissue to replace that lost by injury. Indeed, the depletion of macrophages is unmistakably detrimental to normal skin healing in adult mammals. Yet in certain systems, dermal wounds seem to heal well with limited or even no functional macrophages, creating an apparent paradox regarding the function of this cell in wounds. Recent advances in our understanding of wound macrophage phenotypes, along with new information about cellular plasticity in wounds, may provide some explanation for the apparently contradictory findings and suggest new paradigms regarding macrophage function in wounds. Continued study of this remarkable cell is needed to develop effective therapeutic options to improve healing outcomes.
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spelling pubmed-78334022021-01-26 Macrophages in Healing Wounds: Paradoxes and Paradigms DiPietro, Luisa A. Wilgus, Traci A. Koh, Timothy J. Int J Mol Sci Review Macrophages are prominent cells in normally healing adult skin wounds, yet their exact functions and functional significance to healing outcomes remain enigmatic. Many functional attributes are ascribed to wound macrophages, including host defense and support of the proliferation of new tissue to replace that lost by injury. Indeed, the depletion of macrophages is unmistakably detrimental to normal skin healing in adult mammals. Yet in certain systems, dermal wounds seem to heal well with limited or even no functional macrophages, creating an apparent paradox regarding the function of this cell in wounds. Recent advances in our understanding of wound macrophage phenotypes, along with new information about cellular plasticity in wounds, may provide some explanation for the apparently contradictory findings and suggest new paradigms regarding macrophage function in wounds. Continued study of this remarkable cell is needed to develop effective therapeutic options to improve healing outcomes. MDPI 2021-01-19 /pmc/articles/PMC7833402/ /pubmed/33477945 http://dx.doi.org/10.3390/ijms22020950 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
DiPietro, Luisa A.
Wilgus, Traci A.
Koh, Timothy J.
Macrophages in Healing Wounds: Paradoxes and Paradigms
title Macrophages in Healing Wounds: Paradoxes and Paradigms
title_full Macrophages in Healing Wounds: Paradoxes and Paradigms
title_fullStr Macrophages in Healing Wounds: Paradoxes and Paradigms
title_full_unstemmed Macrophages in Healing Wounds: Paradoxes and Paradigms
title_short Macrophages in Healing Wounds: Paradoxes and Paradigms
title_sort macrophages in healing wounds: paradoxes and paradigms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833402/
https://www.ncbi.nlm.nih.gov/pubmed/33477945
http://dx.doi.org/10.3390/ijms22020950
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