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Macrophages in Healing Wounds: Paradoxes and Paradigms
Macrophages are prominent cells in normally healing adult skin wounds, yet their exact functions and functional significance to healing outcomes remain enigmatic. Many functional attributes are ascribed to wound macrophages, including host defense and support of the proliferation of new tissue to re...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833402/ https://www.ncbi.nlm.nih.gov/pubmed/33477945 http://dx.doi.org/10.3390/ijms22020950 |
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author | DiPietro, Luisa A. Wilgus, Traci A. Koh, Timothy J. |
author_facet | DiPietro, Luisa A. Wilgus, Traci A. Koh, Timothy J. |
author_sort | DiPietro, Luisa A. |
collection | PubMed |
description | Macrophages are prominent cells in normally healing adult skin wounds, yet their exact functions and functional significance to healing outcomes remain enigmatic. Many functional attributes are ascribed to wound macrophages, including host defense and support of the proliferation of new tissue to replace that lost by injury. Indeed, the depletion of macrophages is unmistakably detrimental to normal skin healing in adult mammals. Yet in certain systems, dermal wounds seem to heal well with limited or even no functional macrophages, creating an apparent paradox regarding the function of this cell in wounds. Recent advances in our understanding of wound macrophage phenotypes, along with new information about cellular plasticity in wounds, may provide some explanation for the apparently contradictory findings and suggest new paradigms regarding macrophage function in wounds. Continued study of this remarkable cell is needed to develop effective therapeutic options to improve healing outcomes. |
format | Online Article Text |
id | pubmed-7833402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78334022021-01-26 Macrophages in Healing Wounds: Paradoxes and Paradigms DiPietro, Luisa A. Wilgus, Traci A. Koh, Timothy J. Int J Mol Sci Review Macrophages are prominent cells in normally healing adult skin wounds, yet their exact functions and functional significance to healing outcomes remain enigmatic. Many functional attributes are ascribed to wound macrophages, including host defense and support of the proliferation of new tissue to replace that lost by injury. Indeed, the depletion of macrophages is unmistakably detrimental to normal skin healing in adult mammals. Yet in certain systems, dermal wounds seem to heal well with limited or even no functional macrophages, creating an apparent paradox regarding the function of this cell in wounds. Recent advances in our understanding of wound macrophage phenotypes, along with new information about cellular plasticity in wounds, may provide some explanation for the apparently contradictory findings and suggest new paradigms regarding macrophage function in wounds. Continued study of this remarkable cell is needed to develop effective therapeutic options to improve healing outcomes. MDPI 2021-01-19 /pmc/articles/PMC7833402/ /pubmed/33477945 http://dx.doi.org/10.3390/ijms22020950 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review DiPietro, Luisa A. Wilgus, Traci A. Koh, Timothy J. Macrophages in Healing Wounds: Paradoxes and Paradigms |
title | Macrophages in Healing Wounds: Paradoxes and Paradigms |
title_full | Macrophages in Healing Wounds: Paradoxes and Paradigms |
title_fullStr | Macrophages in Healing Wounds: Paradoxes and Paradigms |
title_full_unstemmed | Macrophages in Healing Wounds: Paradoxes and Paradigms |
title_short | Macrophages in Healing Wounds: Paradoxes and Paradigms |
title_sort | macrophages in healing wounds: paradoxes and paradigms |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833402/ https://www.ncbi.nlm.nih.gov/pubmed/33477945 http://dx.doi.org/10.3390/ijms22020950 |
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