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The effect of race on composite thrombotic events in patients with COVID-19

COVID-19 associated coagulopathy and mortality related to thrombotic complications have been suggested as biological mediators in racial disparities related to COVID-19. We studied the adjusted prevalence of acute ischemic stroke, pulmonary embolism, myocardial infarction, and deep venous thrombosis...

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Autores principales: Esenwa, Charles, Unda, Santiago R., Altschul, David J., Patel, Nikunj K., Malaviya, Avinash, Seiden, Johanna, Lendaris, Andrea, Moncrieffe, Khadean, Labovitz, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833453/
https://www.ncbi.nlm.nih.gov/pubmed/33385794
http://dx.doi.org/10.1016/j.thromres.2020.12.015
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author Esenwa, Charles
Unda, Santiago R.
Altschul, David J.
Patel, Nikunj K.
Malaviya, Avinash
Seiden, Johanna
Lendaris, Andrea
Moncrieffe, Khadean
Labovitz, Daniel L.
author_facet Esenwa, Charles
Unda, Santiago R.
Altschul, David J.
Patel, Nikunj K.
Malaviya, Avinash
Seiden, Johanna
Lendaris, Andrea
Moncrieffe, Khadean
Labovitz, Daniel L.
author_sort Esenwa, Charles
collection PubMed
description COVID-19 associated coagulopathy and mortality related to thrombotic complications have been suggested as biological mediators in racial disparities related to COVID-19. We studied the adjusted prevalence of acute ischemic stroke, pulmonary embolism, myocardial infarction, and deep venous thrombosis stratified by race in hospitalized patients in one New York City borough during the local COVID-19 surge. The multi-racial cohort included 4299 patients hospitalized with COVID-19, 9% of whom were white, 40% black, 41% Hispanic and 10% Asian or other. We found a 6.1% prevalence of composite thrombotic events. There were no significant race-specific differences in thrombotic events when adjusting for basic demographics, socioeconomic factors, medical comorbidities or biomarkers using a stepwise regression model. We therefore found no evidence that the racial disparities related to COVID-19, and specifically thrombotic complications, are caused by biological differences in race.
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spelling pubmed-78334532021-01-26 The effect of race on composite thrombotic events in patients with COVID-19 Esenwa, Charles Unda, Santiago R. Altschul, David J. Patel, Nikunj K. Malaviya, Avinash Seiden, Johanna Lendaris, Andrea Moncrieffe, Khadean Labovitz, Daniel L. Thromb Res Letter to the Editors-in-Chief COVID-19 associated coagulopathy and mortality related to thrombotic complications have been suggested as biological mediators in racial disparities related to COVID-19. We studied the adjusted prevalence of acute ischemic stroke, pulmonary embolism, myocardial infarction, and deep venous thrombosis stratified by race in hospitalized patients in one New York City borough during the local COVID-19 surge. The multi-racial cohort included 4299 patients hospitalized with COVID-19, 9% of whom were white, 40% black, 41% Hispanic and 10% Asian or other. We found a 6.1% prevalence of composite thrombotic events. There were no significant race-specific differences in thrombotic events when adjusting for basic demographics, socioeconomic factors, medical comorbidities or biomarkers using a stepwise regression model. We therefore found no evidence that the racial disparities related to COVID-19, and specifically thrombotic complications, are caused by biological differences in race. Elsevier Ltd. 2021-03 2020-12-29 /pmc/articles/PMC7833453/ /pubmed/33385794 http://dx.doi.org/10.1016/j.thromres.2020.12.015 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Letter to the Editors-in-Chief
Esenwa, Charles
Unda, Santiago R.
Altschul, David J.
Patel, Nikunj K.
Malaviya, Avinash
Seiden, Johanna
Lendaris, Andrea
Moncrieffe, Khadean
Labovitz, Daniel L.
The effect of race on composite thrombotic events in patients with COVID-19
title The effect of race on composite thrombotic events in patients with COVID-19
title_full The effect of race on composite thrombotic events in patients with COVID-19
title_fullStr The effect of race on composite thrombotic events in patients with COVID-19
title_full_unstemmed The effect of race on composite thrombotic events in patients with COVID-19
title_short The effect of race on composite thrombotic events in patients with COVID-19
title_sort effect of race on composite thrombotic events in patients with covid-19
topic Letter to the Editors-in-Chief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833453/
https://www.ncbi.nlm.nih.gov/pubmed/33385794
http://dx.doi.org/10.1016/j.thromres.2020.12.015
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