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Beyond the clot: perfusion imaging of the pulmonary vasculature after COVID-19

A compelling body of evidence points to pulmonary thrombosis and thromboembolism as a key feature of COVID-19. As the pandemic spread across the globe over the past few months, a timely call to arms was issued by a team of clinicians to consider the prospect of long-lasting pulmonary fibrotic damage...

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Autores principales: Dhawan, Ranju T, Gopalan, Deepa, Howard, Luke, Vicente, Angelito, Park, Mirae, Manalan, Kavina, Wallner, Ingrid, Marsden, Peter, Dave, Surendra, Branley, Howard, Russell, Georgina, Dharmarajah, Nishanth, Kon, Onn M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833494/
https://www.ncbi.nlm.nih.gov/pubmed/33217366
http://dx.doi.org/10.1016/S2213-2600(20)30407-0
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author Dhawan, Ranju T
Gopalan, Deepa
Howard, Luke
Vicente, Angelito
Park, Mirae
Manalan, Kavina
Wallner, Ingrid
Marsden, Peter
Dave, Surendra
Branley, Howard
Russell, Georgina
Dharmarajah, Nishanth
Kon, Onn M
author_facet Dhawan, Ranju T
Gopalan, Deepa
Howard, Luke
Vicente, Angelito
Park, Mirae
Manalan, Kavina
Wallner, Ingrid
Marsden, Peter
Dave, Surendra
Branley, Howard
Russell, Georgina
Dharmarajah, Nishanth
Kon, Onn M
author_sort Dhawan, Ranju T
collection PubMed
description A compelling body of evidence points to pulmonary thrombosis and thromboembolism as a key feature of COVID-19. As the pandemic spread across the globe over the past few months, a timely call to arms was issued by a team of clinicians to consider the prospect of long-lasting pulmonary fibrotic damage and plan for structured follow-up. However, the component of post-thrombotic sequelae has been less widely considered. Although the long-term outcomes of COVID-19 are not known, should pulmonary vascular sequelae prove to be clinically significant, these have the potential to become a public health problem. In this Personal View, we propose a proactive follow-up strategy to evaluate residual clot burden, small vessel injury, and potential haemodynamic sequelae. A nuanced and physiological approach to follow-up imaging that looks beyond the clot, at the state of perfusion of lung tissue, is proposed as a key triage tool, with the potential to inform therapeutic strategies.
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spelling pubmed-78334942021-01-26 Beyond the clot: perfusion imaging of the pulmonary vasculature after COVID-19 Dhawan, Ranju T Gopalan, Deepa Howard, Luke Vicente, Angelito Park, Mirae Manalan, Kavina Wallner, Ingrid Marsden, Peter Dave, Surendra Branley, Howard Russell, Georgina Dharmarajah, Nishanth Kon, Onn M Lancet Respir Med Personal View A compelling body of evidence points to pulmonary thrombosis and thromboembolism as a key feature of COVID-19. As the pandemic spread across the globe over the past few months, a timely call to arms was issued by a team of clinicians to consider the prospect of long-lasting pulmonary fibrotic damage and plan for structured follow-up. However, the component of post-thrombotic sequelae has been less widely considered. Although the long-term outcomes of COVID-19 are not known, should pulmonary vascular sequelae prove to be clinically significant, these have the potential to become a public health problem. In this Personal View, we propose a proactive follow-up strategy to evaluate residual clot burden, small vessel injury, and potential haemodynamic sequelae. A nuanced and physiological approach to follow-up imaging that looks beyond the clot, at the state of perfusion of lung tissue, is proposed as a key triage tool, with the potential to inform therapeutic strategies. Elsevier Ltd. 2021-01 2020-11-17 /pmc/articles/PMC7833494/ /pubmed/33217366 http://dx.doi.org/10.1016/S2213-2600(20)30407-0 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Personal View
Dhawan, Ranju T
Gopalan, Deepa
Howard, Luke
Vicente, Angelito
Park, Mirae
Manalan, Kavina
Wallner, Ingrid
Marsden, Peter
Dave, Surendra
Branley, Howard
Russell, Georgina
Dharmarajah, Nishanth
Kon, Onn M
Beyond the clot: perfusion imaging of the pulmonary vasculature after COVID-19
title Beyond the clot: perfusion imaging of the pulmonary vasculature after COVID-19
title_full Beyond the clot: perfusion imaging of the pulmonary vasculature after COVID-19
title_fullStr Beyond the clot: perfusion imaging of the pulmonary vasculature after COVID-19
title_full_unstemmed Beyond the clot: perfusion imaging of the pulmonary vasculature after COVID-19
title_short Beyond the clot: perfusion imaging of the pulmonary vasculature after COVID-19
title_sort beyond the clot: perfusion imaging of the pulmonary vasculature after covid-19
topic Personal View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833494/
https://www.ncbi.nlm.nih.gov/pubmed/33217366
http://dx.doi.org/10.1016/S2213-2600(20)30407-0
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