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A comprehensive spatial-temporal infection model
Motivated by analogies between the spread of infections and of chemical processes, we develop a model that accounts for infection and transport where infected populations correspond to chemical species. Areal densities emerge as the key variables, thus capturing the effect of spatial density. We der...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833503/ https://www.ncbi.nlm.nih.gov/pubmed/33518773 http://dx.doi.org/10.1016/j.ces.2020.116347 |
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author | Ramaswamy, Harisankar Oberai, Assad A. Yortsos, Yannis C. |
author_facet | Ramaswamy, Harisankar Oberai, Assad A. Yortsos, Yannis C. |
author_sort | Ramaswamy, Harisankar |
collection | PubMed |
description | Motivated by analogies between the spread of infections and of chemical processes, we develop a model that accounts for infection and transport where infected populations correspond to chemical species. Areal densities emerge as the key variables, thus capturing the effect of spatial density. We derive expressions for the kinetics of the infection rates, and for the important parameter [Formula: see text] , that include areal density and its spatial distribution. We present results for a batch reactor, the chemical process equivalent of the SIR model, where we examine how the dependence of [Formula: see text] on process extent, the initial density of infected individuals, and fluctuations in population densities effect the progression of the disease. We then consider spatially distributed systems. Diffusion generates traveling waves that propagate at a constant speed, proportional to the square root of the diffusivity and [Formula: see text]. Preliminary analysis shows a similar behavior for the effect of stochastic advection. |
format | Online Article Text |
id | pubmed-7833503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Authors. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78335032021-01-26 A comprehensive spatial-temporal infection model Ramaswamy, Harisankar Oberai, Assad A. Yortsos, Yannis C. Chem Eng Sci Article Motivated by analogies between the spread of infections and of chemical processes, we develop a model that accounts for infection and transport where infected populations correspond to chemical species. Areal densities emerge as the key variables, thus capturing the effect of spatial density. We derive expressions for the kinetics of the infection rates, and for the important parameter [Formula: see text] , that include areal density and its spatial distribution. We present results for a batch reactor, the chemical process equivalent of the SIR model, where we examine how the dependence of [Formula: see text] on process extent, the initial density of infected individuals, and fluctuations in population densities effect the progression of the disease. We then consider spatially distributed systems. Diffusion generates traveling waves that propagate at a constant speed, proportional to the square root of the diffusivity and [Formula: see text]. Preliminary analysis shows a similar behavior for the effect of stochastic advection. The Authors. Published by Elsevier Ltd. 2021-04-06 2021-01-06 /pmc/articles/PMC7833503/ /pubmed/33518773 http://dx.doi.org/10.1016/j.ces.2020.116347 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Ramaswamy, Harisankar Oberai, Assad A. Yortsos, Yannis C. A comprehensive spatial-temporal infection model |
title | A comprehensive spatial-temporal infection model |
title_full | A comprehensive spatial-temporal infection model |
title_fullStr | A comprehensive spatial-temporal infection model |
title_full_unstemmed | A comprehensive spatial-temporal infection model |
title_short | A comprehensive spatial-temporal infection model |
title_sort | comprehensive spatial-temporal infection model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833503/ https://www.ncbi.nlm.nih.gov/pubmed/33518773 http://dx.doi.org/10.1016/j.ces.2020.116347 |
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