Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2

This review describes the sex and gender differences in COVID-19 presentation, treatment, and outcomes. We discuss the differences between the sexes in susceptibility to infection, the role of sex chromosomes on the body's immunologic response and the influence of hormones on the body's re...

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Autores principales: Wolfe, Jeannette, Safdar, Basmah, Madsen, Tracy E., Sethuraman, Kinjal N., Becker, Bruce, Greenberg, Marna Rayl, McGregor, Alyson J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
COVID Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833665/
https://www.ncbi.nlm.nih.gov/pubmed/33583576
http://dx.doi.org/10.1016/j.clinthera.2021.01.015
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author Wolfe, Jeannette
Safdar, Basmah
Madsen, Tracy E.
Sethuraman, Kinjal N.
Becker, Bruce
Greenberg, Marna Rayl
McGregor, Alyson J.
author_facet Wolfe, Jeannette
Safdar, Basmah
Madsen, Tracy E.
Sethuraman, Kinjal N.
Becker, Bruce
Greenberg, Marna Rayl
McGregor, Alyson J.
author_sort Wolfe, Jeannette
collection PubMed
description This review describes the sex and gender differences in COVID-19 presentation, treatment, and outcomes. We discuss the differences between the sexes in susceptibility to infection, the role of sex chromosomes on the body's immunologic response and the influence of hormones on the body's response to the virus. Additionally, the sex differences in clinical and laboratory presentation, complications of infection and outcomes, as well as differences in response to treatment and prevention are reviewed.
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spelling pubmed-78336652021-01-26 Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2 Wolfe, Jeannette Safdar, Basmah Madsen, Tracy E. Sethuraman, Kinjal N. Becker, Bruce Greenberg, Marna Rayl McGregor, Alyson J. Clin Ther COVID Review This review describes the sex and gender differences in COVID-19 presentation, treatment, and outcomes. We discuss the differences between the sexes in susceptibility to infection, the role of sex chromosomes on the body's immunologic response and the influence of hormones on the body's response to the virus. Additionally, the sex differences in clinical and laboratory presentation, complications of infection and outcomes, as well as differences in response to treatment and prevention are reviewed. Elsevier Inc. 2021-03 2021-01-16 /pmc/articles/PMC7833665/ /pubmed/33583576 http://dx.doi.org/10.1016/j.clinthera.2021.01.015 Text en © 2021 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle COVID Review
Wolfe, Jeannette
Safdar, Basmah
Madsen, Tracy E.
Sethuraman, Kinjal N.
Becker, Bruce
Greenberg, Marna Rayl
McGregor, Alyson J.
Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2
title Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2
title_full Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2
title_fullStr Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2
title_full_unstemmed Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2
title_short Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2
title_sort sex- or gender-specific differences in the clinical presentation, outcome, and treatment of sars-cov-2
topic COVID Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833665/
https://www.ncbi.nlm.nih.gov/pubmed/33583576
http://dx.doi.org/10.1016/j.clinthera.2021.01.015
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