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The role of extracellular DNA in COVID-19: Clues from inflamm-aging
Epidemiological data convey severe prognosis and high mortality rate for COVID-19 in elderly men affected by age-related diseases. These subjects develop local and systemic hyper-inflammation, which are associated with thrombotic complications and multi-organ failure. Therefore, understanding SARS-C...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833688/ https://www.ncbi.nlm.nih.gov/pubmed/33321254 http://dx.doi.org/10.1016/j.arr.2020.101234 |
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author | Storci, Gianluca Bonifazi, Francesca Garagnani, Paolo Olivieri, Fabiola Bonafè, Massimiliano |
author_facet | Storci, Gianluca Bonifazi, Francesca Garagnani, Paolo Olivieri, Fabiola Bonafè, Massimiliano |
author_sort | Storci, Gianluca |
collection | PubMed |
description | Epidemiological data convey severe prognosis and high mortality rate for COVID-19 in elderly men affected by age-related diseases. These subjects develop local and systemic hyper-inflammation, which are associated with thrombotic complications and multi-organ failure. Therefore, understanding SARS-CoV-2 induced hyper-inflammation in elderly men is a pressing need. Here we focus on the role of extracellular DNA, mainly mitochondrial DNA (mtDNA) and telomeric DNA (telDNA) in the modulation of systemic inflammation in these subjects. In particular, extracellular mtDNA is regarded as a powerful trigger of the inflammatory response. On the contrary, extracellular telDNA pool is estimated to be capable of inhibiting a variety of inflammatory pathways. In turn, we underpin that telDNA reservoir is progressively depleted during aging, and that it is scarcer in men than in women. We propose that an increase in extracellular mtDNA, concomitant with the reduction of the anti-inflammatory telDNA reservoir may explain hyper-inflammation in elderly male affected by COVID-19. This scenario is reminiscent of inflamm-aging, the portmanteau word that depicts how aging and aging related diseases are intimately linked to inflammation. |
format | Online Article Text |
id | pubmed-7833688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78336882021-01-26 The role of extracellular DNA in COVID-19: Clues from inflamm-aging Storci, Gianluca Bonifazi, Francesca Garagnani, Paolo Olivieri, Fabiola Bonafè, Massimiliano Ageing Res Rev Review Epidemiological data convey severe prognosis and high mortality rate for COVID-19 in elderly men affected by age-related diseases. These subjects develop local and systemic hyper-inflammation, which are associated with thrombotic complications and multi-organ failure. Therefore, understanding SARS-CoV-2 induced hyper-inflammation in elderly men is a pressing need. Here we focus on the role of extracellular DNA, mainly mitochondrial DNA (mtDNA) and telomeric DNA (telDNA) in the modulation of systemic inflammation in these subjects. In particular, extracellular mtDNA is regarded as a powerful trigger of the inflammatory response. On the contrary, extracellular telDNA pool is estimated to be capable of inhibiting a variety of inflammatory pathways. In turn, we underpin that telDNA reservoir is progressively depleted during aging, and that it is scarcer in men than in women. We propose that an increase in extracellular mtDNA, concomitant with the reduction of the anti-inflammatory telDNA reservoir may explain hyper-inflammation in elderly male affected by COVID-19. This scenario is reminiscent of inflamm-aging, the portmanteau word that depicts how aging and aging related diseases are intimately linked to inflammation. Elsevier B.V. 2021-03 2020-12-13 /pmc/articles/PMC7833688/ /pubmed/33321254 http://dx.doi.org/10.1016/j.arr.2020.101234 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Storci, Gianluca Bonifazi, Francesca Garagnani, Paolo Olivieri, Fabiola Bonafè, Massimiliano The role of extracellular DNA in COVID-19: Clues from inflamm-aging |
title | The role of extracellular DNA in COVID-19: Clues from inflamm-aging |
title_full | The role of extracellular DNA in COVID-19: Clues from inflamm-aging |
title_fullStr | The role of extracellular DNA in COVID-19: Clues from inflamm-aging |
title_full_unstemmed | The role of extracellular DNA in COVID-19: Clues from inflamm-aging |
title_short | The role of extracellular DNA in COVID-19: Clues from inflamm-aging |
title_sort | role of extracellular dna in covid-19: clues from inflamm-aging |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833688/ https://www.ncbi.nlm.nih.gov/pubmed/33321254 http://dx.doi.org/10.1016/j.arr.2020.101234 |
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