Detection of sivelestat and its metabolite in small volumes of plasma from Chinese ALI/ARDS patients with SIRS via high-throughput UPLC-MS/MS: A pharmacokinetic study

In this study, we developed a sensitive and efficient analytical approach combining a 96-well plate-based protein precipitation strategy with ultra-performance liquid chromatography electrospray ionization tandem mass spectrometry (UPLC-MS/MS) in order to assess the pharmacokinetic (PK) properties o...

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Detalles Bibliográficos
Autores principales: Liu, Mingzhou, Zhang, Jing, Dong, Lingfang, Xue, Wenhua, He, Qilin, Liang, Wenzhong, Liu, Xing, Zhang, Jingying, Gu, Li, Feng, Yinghua, Yang, Jie, Wang, Haibo, Wang, Yaqin, Li, Kun, Li, Yuanlong, Kong, Weiqin, Zhang, Xiaojian, Yao, Mengying, Wang, Kai, Ma, Peizhi, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833710/
https://www.ncbi.nlm.nih.gov/pubmed/33429252
http://dx.doi.org/10.1016/j.jpba.2020.113876

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