Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale

Existing literature highlights the fact that patients with COVID-19 exhibit alterations in the coagulation process and are associated with respiratory and cardiovascular diseases, including acute respiratory distress syndrome and acute cor pulmonale. In this report, we describe the effects of system...

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Autores principales: Kosanovic, Djuro, Yaroshetskiy, Andrey I., Tsareva, Natalia A., Merzhoeva, Zamira M., Trushenko, Natalia V., Nekludova, Galina V., Schermuly, Ralph Theo, Avdeev, Sergey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833717/
https://www.ncbi.nlm.nih.gov/pubmed/33352323
http://dx.doi.org/10.1016/j.ijid.2020.12.043
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author Kosanovic, Djuro
Yaroshetskiy, Andrey I.
Tsareva, Natalia A.
Merzhoeva, Zamira M.
Trushenko, Natalia V.
Nekludova, Galina V.
Schermuly, Ralph Theo
Avdeev, Sergey N.
author_facet Kosanovic, Djuro
Yaroshetskiy, Andrey I.
Tsareva, Natalia A.
Merzhoeva, Zamira M.
Trushenko, Natalia V.
Nekludova, Galina V.
Schermuly, Ralph Theo
Avdeev, Sergey N.
author_sort Kosanovic, Djuro
collection PubMed
description Existing literature highlights the fact that patients with COVID-19 exhibit alterations in the coagulation process and are associated with respiratory and cardiovascular diseases, including acute respiratory distress syndrome and acute cor pulmonale. In this report, we describe the effects of systemic thrombolysis on acute cor pulmonale in a patient suffering from COVID-19. We demonstrated that systemic thrombolysis successfully improved the hemodynamics of our patient and resulted in a prominent reduction in hypercapnia, alveolar dead space, and ventilatory ratio.
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spelling pubmed-78337172021-01-26 Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale Kosanovic, Djuro Yaroshetskiy, Andrey I. Tsareva, Natalia A. Merzhoeva, Zamira M. Trushenko, Natalia V. Nekludova, Galina V. Schermuly, Ralph Theo Avdeev, Sergey N. Int J Infect Dis Case Report Existing literature highlights the fact that patients with COVID-19 exhibit alterations in the coagulation process and are associated with respiratory and cardiovascular diseases, including acute respiratory distress syndrome and acute cor pulmonale. In this report, we describe the effects of systemic thrombolysis on acute cor pulmonale in a patient suffering from COVID-19. We demonstrated that systemic thrombolysis successfully improved the hemodynamics of our patient and resulted in a prominent reduction in hypercapnia, alveolar dead space, and ventilatory ratio. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-03 2021-01-13 /pmc/articles/PMC7833717/ /pubmed/33352323 http://dx.doi.org/10.1016/j.ijid.2020.12.043 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Kosanovic, Djuro
Yaroshetskiy, Andrey I.
Tsareva, Natalia A.
Merzhoeva, Zamira M.
Trushenko, Natalia V.
Nekludova, Galina V.
Schermuly, Ralph Theo
Avdeev, Sergey N.
Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale
title Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale
title_full Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale
title_fullStr Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale
title_full_unstemmed Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale
title_short Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale
title_sort recombinant tissue plasminogen activator treatment for covid-19 associated ards and acute cor pulmonale
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833717/
https://www.ncbi.nlm.nih.gov/pubmed/33352323
http://dx.doi.org/10.1016/j.ijid.2020.12.043
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