CDK1/2/5 blockade: killing two birds with one stone

Pancreatic ductal adenocarcinoma (PDAC) is an immune resistant tumor. We recently demonstrated that inhibiting CDK1/2/5 by dinaciclib not only blocks immune checkpoint expression, but also triggers histone-dependent immunogenic cell death. This dual mechanism turns immunologically “cold” tumor micro...

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Detalles Bibliográficos
Autores principales: Liu, Jiao, Kang, Rui, Tang, Daolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Author View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833763/
https://www.ncbi.nlm.nih.gov/pubmed/33537177
http://dx.doi.org/10.1080/2162402X.2021.1875612
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author Liu, Jiao
Kang, Rui
Tang, Daolin
author_facet Liu, Jiao
Kang, Rui
Tang, Daolin
author_sort Liu, Jiao
collection PubMed
description Pancreatic ductal adenocarcinoma (PDAC) is an immune resistant tumor. We recently demonstrated that inhibiting CDK1/2/5 by dinaciclib not only blocks immune checkpoint expression, but also triggers histone-dependent immunogenic cell death. This dual mechanism turns immunologically “cold” tumor microenvironment into a “hot” one, improves overall survival rates in mouse PDAC models.
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spelling pubmed-78337632021-02-02 CDK1/2/5 blockade: killing two birds with one stone Liu, Jiao Kang, Rui Tang, Daolin Oncoimmunology Author View Pancreatic ductal adenocarcinoma (PDAC) is an immune resistant tumor. We recently demonstrated that inhibiting CDK1/2/5 by dinaciclib not only blocks immune checkpoint expression, but also triggers histone-dependent immunogenic cell death. This dual mechanism turns immunologically “cold” tumor microenvironment into a “hot” one, improves overall survival rates in mouse PDAC models. Taylor & Francis 2021-01-20 /pmc/articles/PMC7833763/ /pubmed/33537177 http://dx.doi.org/10.1080/2162402X.2021.1875612 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author View
Liu, Jiao
Kang, Rui
Tang, Daolin
CDK1/2/5 blockade: killing two birds with one stone
title CDK1/2/5 blockade: killing two birds with one stone
title_full CDK1/2/5 blockade: killing two birds with one stone
title_fullStr CDK1/2/5 blockade: killing two birds with one stone
title_full_unstemmed CDK1/2/5 blockade: killing two birds with one stone
title_short CDK1/2/5 blockade: killing two birds with one stone
title_sort cdk1/2/5 blockade: killing two birds with one stone
topic Author View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833763/
https://www.ncbi.nlm.nih.gov/pubmed/33537177
http://dx.doi.org/10.1080/2162402X.2021.1875612
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