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CDK1/2/5 blockade: killing two birds with one stone

Pancreatic ductal adenocarcinoma (PDAC) is an immune resistant tumor. We recently demonstrated that inhibiting CDK1/2/5 by dinaciclib not only blocks immune checkpoint expression, but also triggers histone-dependent immunogenic cell death. This dual mechanism turns immunologically “cold” tumor micro...

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Detalles Bibliográficos
Autores principales:	Liu, Jiao, Kang, Rui, Tang, Daolin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Author View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833763/ https://www.ncbi.nlm.nih.gov/pubmed/33537177 http://dx.doi.org/10.1080/2162402X.2021.1875612

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