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Results from the IRoc-GN international registry of patients with COVID-19 and glomerular disease suggest close monitoring

The effects of SARS-CoV-2 infection on individuals with immune-mediated glomerulonephritis, who are often undergoing immunosuppressive treatments, are unknown. Therefore, we created the International Registry of COVID infection in glomerulonephritis (IRoc-GN) and identified 40 patients with glomerul...

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Autores principales: Waldman, Meryl, Soler, Maria Jose, García-Carro, Clara, Lightstone, Liz, Turner-Stokes, Tabitha, Griffith, Megan, Torras, Joan, Valenzuela, Laura Martinez, Bestard, Oriol, Geddes, Colin, Flossmann, Oliver, Budge, Kelly L., Cantarelli, Chiara, Fiaccadori, Enrico, Delsante, Marco, Morales, Enrique, Gutierrez, Eduardo, Niño-Cruz, Jose A., Martinez-Rueda, Armando J., Comai, Giorgia, Bini, Claudia, La Manna, Gaetano, Slon, Maria F., Manrique, Joaquin, Agraz, Irene, Sinaii, Ninet, Cravedi, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Society of Nephrology. Published by Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833801/
https://www.ncbi.nlm.nih.gov/pubmed/33181156
http://dx.doi.org/10.1016/j.kint.2020.10.032
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author Waldman, Meryl
Soler, Maria Jose
García-Carro, Clara
Lightstone, Liz
Turner-Stokes, Tabitha
Griffith, Megan
Torras, Joan
Valenzuela, Laura Martinez
Bestard, Oriol
Geddes, Colin
Flossmann, Oliver
Budge, Kelly L.
Cantarelli, Chiara
Fiaccadori, Enrico
Delsante, Marco
Morales, Enrique
Gutierrez, Eduardo
Niño-Cruz, Jose A.
Martinez-Rueda, Armando J.
Comai, Giorgia
Bini, Claudia
La Manna, Gaetano
Slon, Maria F.
Manrique, Joaquin
Agraz, Irene
Sinaii, Ninet
Cravedi, Paolo
author_facet Waldman, Meryl
Soler, Maria Jose
García-Carro, Clara
Lightstone, Liz
Turner-Stokes, Tabitha
Griffith, Megan
Torras, Joan
Valenzuela, Laura Martinez
Bestard, Oriol
Geddes, Colin
Flossmann, Oliver
Budge, Kelly L.
Cantarelli, Chiara
Fiaccadori, Enrico
Delsante, Marco
Morales, Enrique
Gutierrez, Eduardo
Niño-Cruz, Jose A.
Martinez-Rueda, Armando J.
Comai, Giorgia
Bini, Claudia
La Manna, Gaetano
Slon, Maria F.
Manrique, Joaquin
Agraz, Irene
Sinaii, Ninet
Cravedi, Paolo
author_sort Waldman, Meryl
collection PubMed
description The effects of SARS-CoV-2 infection on individuals with immune-mediated glomerulonephritis, who are often undergoing immunosuppressive treatments, are unknown. Therefore, we created the International Registry of COVID infection in glomerulonephritis (IRoc-GN) and identified 40 patients with glomerulonephritis and COVID-19 followed in centers in North America and Europe. Detailed information on glomerulonephritis diagnosis, kidney parameters, and baseline immunosuppression prior to infection were recorded, as well as clinical presentation, laboratory values, treatment, complications, and outcomes of COVID-19. This cohort was compared to 80 COVID-positive control cases from the general population without glomerulonephritis matched for the time of infection. The majority (70%) of the patients with glomerulonephritis and all the controls were hospitalized. Patients with glomerulonephritis had significantly higher mortality (15% vs. 5%, respectively) and acute kidney injury (39% vs. 14%) than controls, while the need for kidney replacement therapy was not statistically different between the two groups. Receiving immunosuppression or renin-angiotensin-aldosterone system inhibitors at presentation did not increase the risk of death or acute kidney injury in the glomerulonephritis cohort. In the cohort with glomerulonephritis, lower serum albumin at presentation and shorter duration of glomerular disease were associated with greater risk of acute kidney injury and need for kidney replacement therapy. No differences in outcomes occurred between patients with primary glomerulonephritis versus glomerulonephritis associated with a systemic autoimmune disease (lupus or vasculitis). Thus, due to the higher mortality and risk of acute kidney injury than in the general population without glomerulonephritis, patients with glomerulonephritis and COVID-19 should be carefully monitored, especially when they present with low serum albumin levels.
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spelling pubmed-78338012021-01-26 Results from the IRoc-GN international registry of patients with COVID-19 and glomerular disease suggest close monitoring Waldman, Meryl Soler, Maria Jose García-Carro, Clara Lightstone, Liz Turner-Stokes, Tabitha Griffith, Megan Torras, Joan Valenzuela, Laura Martinez Bestard, Oriol Geddes, Colin Flossmann, Oliver Budge, Kelly L. Cantarelli, Chiara Fiaccadori, Enrico Delsante, Marco Morales, Enrique Gutierrez, Eduardo Niño-Cruz, Jose A. Martinez-Rueda, Armando J. Comai, Giorgia Bini, Claudia La Manna, Gaetano Slon, Maria F. Manrique, Joaquin Agraz, Irene Sinaii, Ninet Cravedi, Paolo Kidney Int Clinical Investigation The effects of SARS-CoV-2 infection on individuals with immune-mediated glomerulonephritis, who are often undergoing immunosuppressive treatments, are unknown. Therefore, we created the International Registry of COVID infection in glomerulonephritis (IRoc-GN) and identified 40 patients with glomerulonephritis and COVID-19 followed in centers in North America and Europe. Detailed information on glomerulonephritis diagnosis, kidney parameters, and baseline immunosuppression prior to infection were recorded, as well as clinical presentation, laboratory values, treatment, complications, and outcomes of COVID-19. This cohort was compared to 80 COVID-positive control cases from the general population without glomerulonephritis matched for the time of infection. The majority (70%) of the patients with glomerulonephritis and all the controls were hospitalized. Patients with glomerulonephritis had significantly higher mortality (15% vs. 5%, respectively) and acute kidney injury (39% vs. 14%) than controls, while the need for kidney replacement therapy was not statistically different between the two groups. Receiving immunosuppression or renin-angiotensin-aldosterone system inhibitors at presentation did not increase the risk of death or acute kidney injury in the glomerulonephritis cohort. In the cohort with glomerulonephritis, lower serum albumin at presentation and shorter duration of glomerular disease were associated with greater risk of acute kidney injury and need for kidney replacement therapy. No differences in outcomes occurred between patients with primary glomerulonephritis versus glomerulonephritis associated with a systemic autoimmune disease (lupus or vasculitis). Thus, due to the higher mortality and risk of acute kidney injury than in the general population without glomerulonephritis, patients with glomerulonephritis and COVID-19 should be carefully monitored, especially when they present with low serum albumin levels. International Society of Nephrology. Published by Elsevier Inc. 2021-01 2020-11-09 /pmc/articles/PMC7833801/ /pubmed/33181156 http://dx.doi.org/10.1016/j.kint.2020.10.032 Text en © 2020 International Society of Nephrology. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Clinical Investigation
Waldman, Meryl
Soler, Maria Jose
García-Carro, Clara
Lightstone, Liz
Turner-Stokes, Tabitha
Griffith, Megan
Torras, Joan
Valenzuela, Laura Martinez
Bestard, Oriol
Geddes, Colin
Flossmann, Oliver
Budge, Kelly L.
Cantarelli, Chiara
Fiaccadori, Enrico
Delsante, Marco
Morales, Enrique
Gutierrez, Eduardo
Niño-Cruz, Jose A.
Martinez-Rueda, Armando J.
Comai, Giorgia
Bini, Claudia
La Manna, Gaetano
Slon, Maria F.
Manrique, Joaquin
Agraz, Irene
Sinaii, Ninet
Cravedi, Paolo
Results from the IRoc-GN international registry of patients with COVID-19 and glomerular disease suggest close monitoring
title Results from the IRoc-GN international registry of patients with COVID-19 and glomerular disease suggest close monitoring
title_full Results from the IRoc-GN international registry of patients with COVID-19 and glomerular disease suggest close monitoring
title_fullStr Results from the IRoc-GN international registry of patients with COVID-19 and glomerular disease suggest close monitoring
title_full_unstemmed Results from the IRoc-GN international registry of patients with COVID-19 and glomerular disease suggest close monitoring
title_short Results from the IRoc-GN international registry of patients with COVID-19 and glomerular disease suggest close monitoring
title_sort results from the iroc-gn international registry of patients with covid-19 and glomerular disease suggest close monitoring
topic Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833801/
https://www.ncbi.nlm.nih.gov/pubmed/33181156
http://dx.doi.org/10.1016/j.kint.2020.10.032
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