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Cerebral vasculitis of medium-sized vessels as a possible mechanism of brain damage in COVID-19 patients
BACKGROUND AND PURPOSE: Cerebral complications related to COVID-19 were recently reported, and the underlying mechanisms of brain damage remain uncertain, probably multifactorial. Among various hypotheses suggested, a possible vasculitis was issued but never confirmed. Herein, we aimed to describe b...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Masson SAS.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833894/ https://www.ncbi.nlm.nih.gov/pubmed/33340640 http://dx.doi.org/10.1016/j.neurad.2020.11.004 |
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author | Lersy, François Anheim, Mathieu Willaume, Thibault Chammas, Agathe Brisset, Jean-Christophe Cotton, François Kremer, Stéphane |
author_facet | Lersy, François Anheim, Mathieu Willaume, Thibault Chammas, Agathe Brisset, Jean-Christophe Cotton, François Kremer, Stéphane |
author_sort | Lersy, François |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Cerebral complications related to COVID-19 were recently reported, and the underlying mechanisms of brain damage remain uncertain, probably multifactorial. Among various hypotheses suggested, a possible vasculitis was issued but never confirmed. Herein, we aimed to describe brain MRIs focused on the intracranial vessel wall in a population of COVID-19 patients with neurologic manifestations. MATERIALS AND METHODS: Between March 1 and May 31, 2020, 69 consecutive COVID-19 patients with neurologic manifestations underwent a brain MRI allowing the study of the intracranial vessel wall at Strasbourg University hospitals and were retrospectively included. During the same period, 25 consecutive patients, without suspicion of SARS-CoV-2 infection, underwent a brain MRI urgently, with the same imaging protocols. A vasculitis seemed likely when imaging demonstrated vessel wall thickening with homogeneous and concentric enhancement. RESULTS: Among the 69 COVID-19 patients included, 11 (16%) presented arterial vessel wall thickening with homogeneous and concentric enhancement, compatible with cerebral vasculitis. These neuroimaging findings were not found among the 25 patients without SARS-CoV-2 infection, and the difference was statistically significant (p = 0.03). Middle cerebral arteries, basilar artery, and posterior cerebral arteries were the most frequent vessels involved. For nine of them, imaging demonstrated ischemic or hemorrhagic complications. CONCLUSION: Cerebral vasculitis of medium-sized vessels seems to be one of the mechanisms at the origin of brain damage related to COVID-19. |
format | Online Article Text |
id | pubmed-7833894 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Masson SAS. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78338942021-01-26 Cerebral vasculitis of medium-sized vessels as a possible mechanism of brain damage in COVID-19 patients Lersy, François Anheim, Mathieu Willaume, Thibault Chammas, Agathe Brisset, Jean-Christophe Cotton, François Kremer, Stéphane J Neuroradiol Original Article BACKGROUND AND PURPOSE: Cerebral complications related to COVID-19 were recently reported, and the underlying mechanisms of brain damage remain uncertain, probably multifactorial. Among various hypotheses suggested, a possible vasculitis was issued but never confirmed. Herein, we aimed to describe brain MRIs focused on the intracranial vessel wall in a population of COVID-19 patients with neurologic manifestations. MATERIALS AND METHODS: Between March 1 and May 31, 2020, 69 consecutive COVID-19 patients with neurologic manifestations underwent a brain MRI allowing the study of the intracranial vessel wall at Strasbourg University hospitals and were retrospectively included. During the same period, 25 consecutive patients, without suspicion of SARS-CoV-2 infection, underwent a brain MRI urgently, with the same imaging protocols. A vasculitis seemed likely when imaging demonstrated vessel wall thickening with homogeneous and concentric enhancement. RESULTS: Among the 69 COVID-19 patients included, 11 (16%) presented arterial vessel wall thickening with homogeneous and concentric enhancement, compatible with cerebral vasculitis. These neuroimaging findings were not found among the 25 patients without SARS-CoV-2 infection, and the difference was statistically significant (p = 0.03). Middle cerebral arteries, basilar artery, and posterior cerebral arteries were the most frequent vessels involved. For nine of them, imaging demonstrated ischemic or hemorrhagic complications. CONCLUSION: Cerebral vasculitis of medium-sized vessels seems to be one of the mechanisms at the origin of brain damage related to COVID-19. Elsevier Masson SAS. 2021-05 2020-12-16 /pmc/articles/PMC7833894/ /pubmed/33340640 http://dx.doi.org/10.1016/j.neurad.2020.11.004 Text en © 2020 Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Lersy, François Anheim, Mathieu Willaume, Thibault Chammas, Agathe Brisset, Jean-Christophe Cotton, François Kremer, Stéphane Cerebral vasculitis of medium-sized vessels as a possible mechanism of brain damage in COVID-19 patients |
title | Cerebral vasculitis of medium-sized vessels as a possible mechanism of brain damage in COVID-19 patients |
title_full | Cerebral vasculitis of medium-sized vessels as a possible mechanism of brain damage in COVID-19 patients |
title_fullStr | Cerebral vasculitis of medium-sized vessels as a possible mechanism of brain damage in COVID-19 patients |
title_full_unstemmed | Cerebral vasculitis of medium-sized vessels as a possible mechanism of brain damage in COVID-19 patients |
title_short | Cerebral vasculitis of medium-sized vessels as a possible mechanism of brain damage in COVID-19 patients |
title_sort | cerebral vasculitis of medium-sized vessels as a possible mechanism of brain damage in covid-19 patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833894/ https://www.ncbi.nlm.nih.gov/pubmed/33340640 http://dx.doi.org/10.1016/j.neurad.2020.11.004 |
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