Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19

Recent data have revealed that fructose-rich diet triggers inflammation and lipid synthesis. Furthermore, lipid metabolism, cholesterol synthesis and sterol regulatory element binding protein-2 (SREBP-2) activation correlates with coronavirus disease 2019 (COVID-19)-induced cytokine storm. High fruc...

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Detalles Bibliográficos
Autores principales: Sohrabi, Yahya, Reinecke, Holger, Godfrey, Rinesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833986/
https://www.ncbi.nlm.nih.gov/pubmed/33455862
http://dx.doi.org/10.1016/j.tem.2021.01.001
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author Sohrabi, Yahya
Reinecke, Holger
Godfrey, Rinesh
author_facet Sohrabi, Yahya
Reinecke, Holger
Godfrey, Rinesh
author_sort Sohrabi, Yahya
collection PubMed
description Recent data have revealed that fructose-rich diet triggers inflammation and lipid synthesis. Furthermore, lipid metabolism, cholesterol synthesis and sterol regulatory element binding protein-2 (SREBP-2) activation correlates with coronavirus disease 2019 (COVID-19)-induced cytokine storm. High fructose consumption result in SREBPs activation, altered cholesterol and lipid synthesis and may establish an innate immune memory in the cells, leading to severe COVID-19 in patients with obesity.
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spelling pubmed-78339862021-01-26 Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19 Sohrabi, Yahya Reinecke, Holger Godfrey, Rinesh Trends Endocrinol Metab Spotlight Recent data have revealed that fructose-rich diet triggers inflammation and lipid synthesis. Furthermore, lipid metabolism, cholesterol synthesis and sterol regulatory element binding protein-2 (SREBP-2) activation correlates with coronavirus disease 2019 (COVID-19)-induced cytokine storm. High fructose consumption result in SREBPs activation, altered cholesterol and lipid synthesis and may establish an innate immune memory in the cells, leading to severe COVID-19 in patients with obesity. Elsevier Ltd. 2021-03 2021-01-08 /pmc/articles/PMC7833986/ /pubmed/33455862 http://dx.doi.org/10.1016/j.tem.2021.01.001 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Spotlight
Sohrabi, Yahya
Reinecke, Holger
Godfrey, Rinesh
Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19
title Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19
title_full Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19
title_fullStr Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19
title_full_unstemmed Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19
title_short Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19
title_sort altered cholesterol and lipid synthesis mediates hyperinflammation in covid-19
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833986/
https://www.ncbi.nlm.nih.gov/pubmed/33455862
http://dx.doi.org/10.1016/j.tem.2021.01.001
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