Disrupting enzyme fluidity

A combination of X-ray crystallography, NMR, and mass spectrometry has revealed how diverse small-molecule inhibitors bind Bruton’s tyrosine kinase and alter the conformation of this enzyme.

Detalles Bibliográficos
Autor principal: Anand, Ganesh Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834015/
https://www.ncbi.nlm.nih.gov/pubmed/33492229
http://dx.doi.org/10.7554/eLife.65221
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author Anand, Ganesh Srinivasan
author_facet Anand, Ganesh Srinivasan
author_sort Anand, Ganesh Srinivasan
collection PubMed
description A combination of X-ray crystallography, NMR, and mass spectrometry has revealed how diverse small-molecule inhibitors bind Bruton’s tyrosine kinase and alter the conformation of this enzyme.
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spelling pubmed-78340152021-01-27 Disrupting enzyme fluidity Anand, Ganesh Srinivasan eLife Structural Biology and Molecular Biophysics A combination of X-ray crystallography, NMR, and mass spectrometry has revealed how diverse small-molecule inhibitors bind Bruton’s tyrosine kinase and alter the conformation of this enzyme. eLife Sciences Publications, Ltd 2021-01-25 /pmc/articles/PMC7834015/ /pubmed/33492229 http://dx.doi.org/10.7554/eLife.65221 Text en © 2021, Anand http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Structural Biology and Molecular Biophysics
Anand, Ganesh Srinivasan
Disrupting enzyme fluidity
title Disrupting enzyme fluidity
title_full Disrupting enzyme fluidity
title_fullStr Disrupting enzyme fluidity
title_full_unstemmed Disrupting enzyme fluidity
title_short Disrupting enzyme fluidity
title_sort disrupting enzyme fluidity
topic Structural Biology and Molecular Biophysics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834015/
https://www.ncbi.nlm.nih.gov/pubmed/33492229
http://dx.doi.org/10.7554/eLife.65221
work_keys_str_mv AT anandganeshsrinivasan disruptingenzymefluidity

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