Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity

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Poly(ADP-ribose) polymerase (PARP) superfamily members covalently link either a single ADP-ribose (ADPR) or a chain of ADPR units to proteins using NAD as the source of ADPR. Although the well-known poly(ADP-ribosylating) (PARylating) PARPs primarily function in the DNA damage response, many noncano...

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Detalles Bibliográficos
Autores principales: Heer, Collin D., Sanderson, Daniel J., Voth, Lynden S., Alhammad, Yousef M.O., Schmidt, Mark S., Trammell, Samuel A.J., Perlman, Stanley, Cohen, Michael S., Fehr, Anthony R., Brenner, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834058/
https://www.ncbi.nlm.nih.gov/pubmed/33051211
http://dx.doi.org/10.1074/jbc.RA120.015138
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