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The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment
The recent outbreak of the corona virus disease (COVID-19) has had major global impact. The relationship between severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection and psychiatric diseases is of great concern, with an evident link between corona virus infections and various central...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier Masson SAS.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834135/ https://www.ncbi.nlm.nih.gov/pubmed/33421734 http://dx.doi.org/10.1016/j.biopha.2020.111200 |
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author | Jansen van Vuren, Esmé Steyn, Stephan F. Brink, Christiaan B. Möller, Marisa Viljoen, Francois P. Harvey, Brian H. |
author_facet | Jansen van Vuren, Esmé Steyn, Stephan F. Brink, Christiaan B. Möller, Marisa Viljoen, Francois P. Harvey, Brian H. |
author_sort | Jansen van Vuren, Esmé |
collection | PubMed |
description | The recent outbreak of the corona virus disease (COVID-19) has had major global impact. The relationship between severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection and psychiatric diseases is of great concern, with an evident link between corona virus infections and various central and peripheral nervous system manifestations. Unmitigated neuro-inflammation has been noted to underlie not only the severe respiratory complications of the disease but is also present in a range of neuro-psychiatric illnesses. Several neurological and psychiatric disorders are characterized by immune-inflammatory states, while treatments for these disorders have distinct anti-inflammatory properties and effects. With inflammation being a common contributing factor in SARS-CoV-2, as well as psychiatric disorders, treatment of either condition may affect disease progression of the other or alter response to pharmacological treatment. In this review, we elucidate how viral infections could affect pre-existing psychiatric conditions and how pharmacological treatments of these conditions may affect overall progress and outcome in the treatment of SARS-CoV-2. We address whether any treatment-induced benefits and potential adverse effects may ultimately affect the overall treatment approach, considering the underlying dysregulated neuro-inflammatory processes and potential drug interactions. Finally, we suggest adjunctive treatment options for SARS-CoV-2-associated neuro-psychiatric symptoms. |
format | Online Article Text |
id | pubmed-7834135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Authors. Published by Elsevier Masson SAS. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78341352021-01-26 The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment Jansen van Vuren, Esmé Steyn, Stephan F. Brink, Christiaan B. Möller, Marisa Viljoen, Francois P. Harvey, Brian H. Biomed Pharmacother Review The recent outbreak of the corona virus disease (COVID-19) has had major global impact. The relationship between severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection and psychiatric diseases is of great concern, with an evident link between corona virus infections and various central and peripheral nervous system manifestations. Unmitigated neuro-inflammation has been noted to underlie not only the severe respiratory complications of the disease but is also present in a range of neuro-psychiatric illnesses. Several neurological and psychiatric disorders are characterized by immune-inflammatory states, while treatments for these disorders have distinct anti-inflammatory properties and effects. With inflammation being a common contributing factor in SARS-CoV-2, as well as psychiatric disorders, treatment of either condition may affect disease progression of the other or alter response to pharmacological treatment. In this review, we elucidate how viral infections could affect pre-existing psychiatric conditions and how pharmacological treatments of these conditions may affect overall progress and outcome in the treatment of SARS-CoV-2. We address whether any treatment-induced benefits and potential adverse effects may ultimately affect the overall treatment approach, considering the underlying dysregulated neuro-inflammatory processes and potential drug interactions. Finally, we suggest adjunctive treatment options for SARS-CoV-2-associated neuro-psychiatric symptoms. The Authors. Published by Elsevier Masson SAS. 2021-03 2021-01-01 /pmc/articles/PMC7834135/ /pubmed/33421734 http://dx.doi.org/10.1016/j.biopha.2020.111200 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Jansen van Vuren, Esmé Steyn, Stephan F. Brink, Christiaan B. Möller, Marisa Viljoen, Francois P. Harvey, Brian H. The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment |
title | The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment |
title_full | The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment |
title_fullStr | The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment |
title_full_unstemmed | The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment |
title_short | The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment |
title_sort | neuropsychiatric manifestations of covid-19: interactions with psychiatric illness and pharmacological treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834135/ https://www.ncbi.nlm.nih.gov/pubmed/33421734 http://dx.doi.org/10.1016/j.biopha.2020.111200 |
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