PD-1-Expressing SARS-CoV-2-Specific CD8(+) T Cells Are Not Exhausted, but Functional in Patients with COVID-19

Memory T cell responses have been demonstrated in COVID-19 convalescents, but ex vivo phenotypes of SARS-CoV-2-specific T cells have been unclear. We detected SARS-CoV-2-specific CD8(+) T cells by MHC class I multimer staining and examined their phenotypes and functions in acute and convalescent COV...

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Autores principales: Rha, Min-Seok, Jeong, Hye Won, Ko, Jae-Hoon, Choi, Seong Jin, Seo, In-Ho, Lee, Jeong Seok, Sa, Moa, Kim, A Reum, Joo, Eun-Jeong, Ahn, Jin Young, Kim, Jung Ho, Song, Kyoung-Ho, Kim, Eu Suk, Oh, Dong Hyun, Ahn, Mi Young, Choi, Hee Kyoung, Jeon, Ji Hoon, Choi, Jae-Phil, Kim, Hong Bin, Kim, Young Keun, Park, Su-Hyung, Choi, Won Suk, Choi, Jun Yong, Peck, Kyong Ran, Shin, Eui-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834198/
https://www.ncbi.nlm.nih.gov/pubmed/33338412
http://dx.doi.org/10.1016/j.immuni.2020.12.002

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