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Stability analysis and optimal control of covid-19 with convex incidence rate in Khyber Pakhtunkhawa (Pakistan)
The dynamic of covid-19 epidemic model with a convex incidence rate is studied in this article. First, we formulate the model without control and study all the basic properties and results including local and global stability. We show the global stability of disease free equilibrium using the method...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier B.V.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834202/ https://www.ncbi.nlm.nih.gov/pubmed/33520623 http://dx.doi.org/10.1016/j.rinp.2020.103703 |
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author | Khan, Amir Zarin, Rahat Hussain, Ghulam Ahmad, Noor Atinah Mohd, Mohd Hafiz Yusuf, Abdullahi |
author_facet | Khan, Amir Zarin, Rahat Hussain, Ghulam Ahmad, Noor Atinah Mohd, Mohd Hafiz Yusuf, Abdullahi |
author_sort | Khan, Amir |
collection | PubMed |
description | The dynamic of covid-19 epidemic model with a convex incidence rate is studied in this article. First, we formulate the model without control and study all the basic properties and results including local and global stability. We show the global stability of disease free equilibrium using the method of Lyapunov function theory while for disease endemic, we use the method of geometrical approach. Furthermore, we develop a model with suitable optimal control strategies. Our aim is to minimize the infection in the host population. In order to do this, we use two control variables. Moreover, sensitivity analysis complemented by simulations are performed to determine how changes in parameters affect the dynamical behavior of the system. Taking into account the central manifold theory the bifurcation analysis is also incorporated. The numerical simulations are performed in order to show the feasibility of the control strategy and effectiveness of the theoretical results. |
format | Online Article Text |
id | pubmed-7834202 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Authors. Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78342022021-01-26 Stability analysis and optimal control of covid-19 with convex incidence rate in Khyber Pakhtunkhawa (Pakistan) Khan, Amir Zarin, Rahat Hussain, Ghulam Ahmad, Noor Atinah Mohd, Mohd Hafiz Yusuf, Abdullahi Results Phys Article The dynamic of covid-19 epidemic model with a convex incidence rate is studied in this article. First, we formulate the model without control and study all the basic properties and results including local and global stability. We show the global stability of disease free equilibrium using the method of Lyapunov function theory while for disease endemic, we use the method of geometrical approach. Furthermore, we develop a model with suitable optimal control strategies. Our aim is to minimize the infection in the host population. In order to do this, we use two control variables. Moreover, sensitivity analysis complemented by simulations are performed to determine how changes in parameters affect the dynamical behavior of the system. Taking into account the central manifold theory the bifurcation analysis is also incorporated. The numerical simulations are performed in order to show the feasibility of the control strategy and effectiveness of the theoretical results. The Authors. Published by Elsevier B.V. 2021-01 2020-12-17 /pmc/articles/PMC7834202/ /pubmed/33520623 http://dx.doi.org/10.1016/j.rinp.2020.103703 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Khan, Amir Zarin, Rahat Hussain, Ghulam Ahmad, Noor Atinah Mohd, Mohd Hafiz Yusuf, Abdullahi Stability analysis and optimal control of covid-19 with convex incidence rate in Khyber Pakhtunkhawa (Pakistan) |
title | Stability analysis and optimal control of covid-19 with convex incidence rate in Khyber Pakhtunkhawa (Pakistan) |
title_full | Stability analysis and optimal control of covid-19 with convex incidence rate in Khyber Pakhtunkhawa (Pakistan) |
title_fullStr | Stability analysis and optimal control of covid-19 with convex incidence rate in Khyber Pakhtunkhawa (Pakistan) |
title_full_unstemmed | Stability analysis and optimal control of covid-19 with convex incidence rate in Khyber Pakhtunkhawa (Pakistan) |
title_short | Stability analysis and optimal control of covid-19 with convex incidence rate in Khyber Pakhtunkhawa (Pakistan) |
title_sort | stability analysis and optimal control of covid-19 with convex incidence rate in khyber pakhtunkhawa (pakistan) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834202/ https://www.ncbi.nlm.nih.gov/pubmed/33520623 http://dx.doi.org/10.1016/j.rinp.2020.103703 |
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