SARS-CoV-2 and the sympathetic immune response: Dampening inflammation with antihypertensive drugs (Clonidine and Propranolol)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a pandemic with the United States now carrying the highest number of cases and fatalities. Although vaccines and antiviral agents are the main focus of therapy, here we present a plausible hypothesis to leverage our understanding of...

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Detalles Bibliográficos
Autores principales: Hyoju, Sanjiv K, Zaborina, Olga, van Goor, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834242/
https://www.ncbi.nlm.nih.gov/pubmed/32758881
http://dx.doi.org/10.1016/j.mehy.2020.110039
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author Hyoju, Sanjiv K
Zaborina, Olga
van Goor, Harry
author_facet Hyoju, Sanjiv K
Zaborina, Olga
van Goor, Harry
author_sort Hyoju, Sanjiv K
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a pandemic with the United States now carrying the highest number of cases and fatalities. Although vaccines and antiviral agents are the main focus of therapy, here we present a plausible hypothesis to leverage our understanding of neuroimmunomodulation to intervene in the pathophysiology of the disease to prevent death.
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spelling pubmed-78342422021-01-26 SARS-CoV-2 and the sympathetic immune response: Dampening inflammation with antihypertensive drugs (Clonidine and Propranolol) Hyoju, Sanjiv K Zaborina, Olga van Goor, Harry Med Hypotheses Article Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a pandemic with the United States now carrying the highest number of cases and fatalities. Although vaccines and antiviral agents are the main focus of therapy, here we present a plausible hypothesis to leverage our understanding of neuroimmunomodulation to intervene in the pathophysiology of the disease to prevent death. Elsevier Ltd. 2020-11 2020-06-24 /pmc/articles/PMC7834242/ /pubmed/32758881 http://dx.doi.org/10.1016/j.mehy.2020.110039 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Hyoju, Sanjiv K
Zaborina, Olga
van Goor, Harry
SARS-CoV-2 and the sympathetic immune response: Dampening inflammation with antihypertensive drugs (Clonidine and Propranolol)
title SARS-CoV-2 and the sympathetic immune response: Dampening inflammation with antihypertensive drugs (Clonidine and Propranolol)
title_full SARS-CoV-2 and the sympathetic immune response: Dampening inflammation with antihypertensive drugs (Clonidine and Propranolol)
title_fullStr SARS-CoV-2 and the sympathetic immune response: Dampening inflammation with antihypertensive drugs (Clonidine and Propranolol)
title_full_unstemmed SARS-CoV-2 and the sympathetic immune response: Dampening inflammation with antihypertensive drugs (Clonidine and Propranolol)
title_short SARS-CoV-2 and the sympathetic immune response: Dampening inflammation with antihypertensive drugs (Clonidine and Propranolol)
title_sort sars-cov-2 and the sympathetic immune response: dampening inflammation with antihypertensive drugs (clonidine and propranolol)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834242/
https://www.ncbi.nlm.nih.gov/pubmed/32758881
http://dx.doi.org/10.1016/j.mehy.2020.110039
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