A hypothesis about the role of fetal hemoglobin in COVID-19

COVID-19 infection is less common in children (with higher fetal hemoglobin levels). In our preliminary study, we also observed a low prevalence and fatality of COVID-19 in countries with high rate of hemoglobinopathy carries. Given these two facts, the hemoglobin structure can play a role in the ph...

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Detalles Bibliográficos
Autores principales: Sotoudeh, Ehsan, Sotoudeh, Houman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834262/
https://www.ncbi.nlm.nih.gov/pubmed/32570166
http://dx.doi.org/10.1016/j.mehy.2020.109994
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author Sotoudeh, Ehsan
Sotoudeh, Houman
author_facet Sotoudeh, Ehsan
Sotoudeh, Houman
author_sort Sotoudeh, Ehsan
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description COVID-19 infection is less common in children (with higher fetal hemoglobin levels). In our preliminary study, we also observed a low prevalence and fatality of COVID-19 in countries with high rate of hemoglobinopathy carries. Given these two facts, the hemoglobin structure can play a role in the physiopathology of COVID-19 disease. Several drugs are known to increase fetal hemoglobin in adults. Adding these drugs to COVID-19 clinical trials may improve the patients’ outcomes.
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spelling pubmed-78342622021-01-26 A hypothesis about the role of fetal hemoglobin in COVID-19 Sotoudeh, Ehsan Sotoudeh, Houman Med Hypotheses Article COVID-19 infection is less common in children (with higher fetal hemoglobin levels). In our preliminary study, we also observed a low prevalence and fatality of COVID-19 in countries with high rate of hemoglobinopathy carries. Given these two facts, the hemoglobin structure can play a role in the physiopathology of COVID-19 disease. Several drugs are known to increase fetal hemoglobin in adults. Adding these drugs to COVID-19 clinical trials may improve the patients’ outcomes. Elsevier Ltd. 2020-11 2020-06-12 /pmc/articles/PMC7834262/ /pubmed/32570166 http://dx.doi.org/10.1016/j.mehy.2020.109994 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Sotoudeh, Ehsan
Sotoudeh, Houman
A hypothesis about the role of fetal hemoglobin in COVID-19
title A hypothesis about the role of fetal hemoglobin in COVID-19
title_full A hypothesis about the role of fetal hemoglobin in COVID-19
title_fullStr A hypothesis about the role of fetal hemoglobin in COVID-19
title_full_unstemmed A hypothesis about the role of fetal hemoglobin in COVID-19
title_short A hypothesis about the role of fetal hemoglobin in COVID-19
title_sort hypothesis about the role of fetal hemoglobin in covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834262/
https://www.ncbi.nlm.nih.gov/pubmed/32570166
http://dx.doi.org/10.1016/j.mehy.2020.109994
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