Adsorptive granulocyte and monocyte apheresis: A potentially relevant therapeutic option for COVID-19

The overproduction of proinflammatory cytokines and subsequent thromboembolism are major problems of coronavirus disease 2019 (COVID-19). Adsorptive granulocyte and monocyte apheresis (GMA), used for ulcerative colitis, is an extracorporeal therapy designed to remove activated myeloid lineage cells....

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Autores principales: Kanekura, Takuro, Kawahara, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834290/
https://www.ncbi.nlm.nih.gov/pubmed/32721534
http://dx.doi.org/10.1016/j.ijid.2020.07.025
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author Kanekura, Takuro
Kawahara, Koichi
author_facet Kanekura, Takuro
Kawahara, Koichi
author_sort Kanekura, Takuro
collection PubMed
description The overproduction of proinflammatory cytokines and subsequent thromboembolism are major problems of coronavirus disease 2019 (COVID-19). Adsorptive granulocyte and monocyte apheresis (GMA), used for ulcerative colitis, is an extracorporeal therapy designed to remove activated myeloid lineage cells. Previous studies have demonstrated that GMA decreases proinflammatory cytokines and neutrophil–platelet aggregates. The effect of GMA on COVID-19 in a patient with ulcerative colitis was recently reported. The modes of action of GMA together with the findings of this case report indicate that GMA could be a relevant treatment option for COVID-19.
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spelling pubmed-78342902021-01-26 Adsorptive granulocyte and monocyte apheresis: A potentially relevant therapeutic option for COVID-19 Kanekura, Takuro Kawahara, Koichi Int J Infect Dis Article The overproduction of proinflammatory cytokines and subsequent thromboembolism are major problems of coronavirus disease 2019 (COVID-19). Adsorptive granulocyte and monocyte apheresis (GMA), used for ulcerative colitis, is an extracorporeal therapy designed to remove activated myeloid lineage cells. Previous studies have demonstrated that GMA decreases proinflammatory cytokines and neutrophil–platelet aggregates. The effect of GMA on COVID-19 in a patient with ulcerative colitis was recently reported. The modes of action of GMA together with the findings of this case report indicate that GMA could be a relevant treatment option for COVID-19. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020-10 2020-07-25 /pmc/articles/PMC7834290/ /pubmed/32721534 http://dx.doi.org/10.1016/j.ijid.2020.07.025 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Kanekura, Takuro
Kawahara, Koichi
Adsorptive granulocyte and monocyte apheresis: A potentially relevant therapeutic option for COVID-19
title Adsorptive granulocyte and monocyte apheresis: A potentially relevant therapeutic option for COVID-19
title_full Adsorptive granulocyte and monocyte apheresis: A potentially relevant therapeutic option for COVID-19
title_fullStr Adsorptive granulocyte and monocyte apheresis: A potentially relevant therapeutic option for COVID-19
title_full_unstemmed Adsorptive granulocyte and monocyte apheresis: A potentially relevant therapeutic option for COVID-19
title_short Adsorptive granulocyte and monocyte apheresis: A potentially relevant therapeutic option for COVID-19
title_sort adsorptive granulocyte and monocyte apheresis: a potentially relevant therapeutic option for covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834290/
https://www.ncbi.nlm.nih.gov/pubmed/32721534
http://dx.doi.org/10.1016/j.ijid.2020.07.025
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