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Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19)
The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 posi...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier B.V.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834390/ https://www.ncbi.nlm.nih.gov/pubmed/33418027 http://dx.doi.org/10.1016/j.virusres.2020.198283 |
| _version_ | 1783642270541545472 |
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| author | Scagnolari, Carolina Pierangeli, Alessandra Frasca, Federica Bitossi, Camilla Viscido, Agnese Oliveto, Giuseppe Scordio, Mirko Mazzuti, Laura Di Carlo, Daniele Gentile, Massimo Solimini, Angelo Ceccarelli, Giancarlo Pugliese, Francesco Mastroianni, Claudio Maria d’Ettorre, Gabriella Turriziani, Ombretta Antonelli, Guido |
| author_facet | Scagnolari, Carolina Pierangeli, Alessandra Frasca, Federica Bitossi, Camilla Viscido, Agnese Oliveto, Giuseppe Scordio, Mirko Mazzuti, Laura Di Carlo, Daniele Gentile, Massimo Solimini, Angelo Ceccarelli, Giancarlo Pugliese, Francesco Mastroianni, Claudio Maria d’Ettorre, Gabriella Turriziani, Ombretta Antonelli, Guido |
| author_sort | Scagnolari, Carolina |
| collection | PubMed |
| description | The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 severity. |
| format | Online Article Text |
| id | pubmed-7834390 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Elsevier B.V. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-78343902021-01-26 Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19) Scagnolari, Carolina Pierangeli, Alessandra Frasca, Federica Bitossi, Camilla Viscido, Agnese Oliveto, Giuseppe Scordio, Mirko Mazzuti, Laura Di Carlo, Daniele Gentile, Massimo Solimini, Angelo Ceccarelli, Giancarlo Pugliese, Francesco Mastroianni, Claudio Maria d’Ettorre, Gabriella Turriziani, Ombretta Antonelli, Guido Virus Res Short Communication The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 severity. Elsevier B.V. 2021-04-02 2021-01-05 /pmc/articles/PMC7834390/ /pubmed/33418027 http://dx.doi.org/10.1016/j.virusres.2020.198283 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Short Communication Scagnolari, Carolina Pierangeli, Alessandra Frasca, Federica Bitossi, Camilla Viscido, Agnese Oliveto, Giuseppe Scordio, Mirko Mazzuti, Laura Di Carlo, Daniele Gentile, Massimo Solimini, Angelo Ceccarelli, Giancarlo Pugliese, Francesco Mastroianni, Claudio Maria d’Ettorre, Gabriella Turriziani, Ombretta Antonelli, Guido Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19) |
| title | Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19) |
| title_full | Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19) |
| title_fullStr | Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19) |
| title_full_unstemmed | Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19) |
| title_short | Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19) |
| title_sort | differential induction of type i and iii interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (covid-19) |
| topic | Short Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834390/ https://www.ncbi.nlm.nih.gov/pubmed/33418027 http://dx.doi.org/10.1016/j.virusres.2020.198283 |
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