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A parametrized nonlinear predictive control strategy for relaxing COVID-19 social distancing measures in Brazil

The SARS-CoV-2 virus was first registered in Brazil by the end of February 2020. Since then, the country counts over 150000 deaths due to COVID-19 and faces a profound social and economic crisis; there is also an ongoing health catastrophe, with the majority of hospital beds in many Brazilian cities...

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Detalles Bibliográficos
Autores principales: Morato, Marcelo M., Pataro, Igor M.L., Americano da Costa, Marcus V., Normey-Rico, Julio E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: ISA. Published by Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834916/
https://www.ncbi.nlm.nih.gov/pubmed/33309260
http://dx.doi.org/10.1016/j.isatra.2020.12.012
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author Morato, Marcelo M.
Pataro, Igor M.L.
Americano da Costa, Marcus V.
Normey-Rico, Julio E.
author_facet Morato, Marcelo M.
Pataro, Igor M.L.
Americano da Costa, Marcus V.
Normey-Rico, Julio E.
author_sort Morato, Marcelo M.
collection PubMed
description The SARS-CoV-2 virus was first registered in Brazil by the end of February 2020. Since then, the country counts over 150000 deaths due to COVID-19 and faces a profound social and economic crisis; there is also an ongoing health catastrophe, with the majority of hospital beds in many Brazilian cities currently occupied with COVID-19 patients. Thus, a Nonlinear Model Predictive Control (NMPC) scheme used to plan appropriate social distancing measures (and relaxations) in order to mitigate the effects of this pandemic is formulated in this paper. The strategy is designed upon an adapted data-driven Susceptible–Infected–Recovered–Deceased (SIRD) model, which includes time-varying auto-regressive immunological parameters. A novel identification procedure is proposed, composed of analytical regressions, Least-Squares optimization and auto-regressive model fits. The adapted SIRD model is validated with real data and able to adequately represent the contagion curves over large forecast horizons. The NMPC strategy is designed to generate piecewise constant quarantine guidelines, which can be reassessed (relaxed/strengthened) each week. Simulation results show that the proposed NMPC technique is able to mitigate the number of infections and progressively loosen social distancing measures. With respect to a “no-control” condition, the number of deaths could be reduced in up to 30% if the proposed NMPC coordinated health policy measures are enacted.
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spelling pubmed-78349162021-01-26 A parametrized nonlinear predictive control strategy for relaxing COVID-19 social distancing measures in Brazil Morato, Marcelo M. Pataro, Igor M.L. Americano da Costa, Marcus V. Normey-Rico, Julio E. ISA Trans Research Article The SARS-CoV-2 virus was first registered in Brazil by the end of February 2020. Since then, the country counts over 150000 deaths due to COVID-19 and faces a profound social and economic crisis; there is also an ongoing health catastrophe, with the majority of hospital beds in many Brazilian cities currently occupied with COVID-19 patients. Thus, a Nonlinear Model Predictive Control (NMPC) scheme used to plan appropriate social distancing measures (and relaxations) in order to mitigate the effects of this pandemic is formulated in this paper. The strategy is designed upon an adapted data-driven Susceptible–Infected–Recovered–Deceased (SIRD) model, which includes time-varying auto-regressive immunological parameters. A novel identification procedure is proposed, composed of analytical regressions, Least-Squares optimization and auto-regressive model fits. The adapted SIRD model is validated with real data and able to adequately represent the contagion curves over large forecast horizons. The NMPC strategy is designed to generate piecewise constant quarantine guidelines, which can be reassessed (relaxed/strengthened) each week. Simulation results show that the proposed NMPC technique is able to mitigate the number of infections and progressively loosen social distancing measures. With respect to a “no-control” condition, the number of deaths could be reduced in up to 30% if the proposed NMPC coordinated health policy measures are enacted. ISA. Published by Elsevier Ltd. 2022-05 2020-12-08 /pmc/articles/PMC7834916/ /pubmed/33309260 http://dx.doi.org/10.1016/j.isatra.2020.12.012 Text en © 2020 ISA. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Research Article
Morato, Marcelo M.
Pataro, Igor M.L.
Americano da Costa, Marcus V.
Normey-Rico, Julio E.
A parametrized nonlinear predictive control strategy for relaxing COVID-19 social distancing measures in Brazil
title A parametrized nonlinear predictive control strategy for relaxing COVID-19 social distancing measures in Brazil
title_full A parametrized nonlinear predictive control strategy for relaxing COVID-19 social distancing measures in Brazil
title_fullStr A parametrized nonlinear predictive control strategy for relaxing COVID-19 social distancing measures in Brazil
title_full_unstemmed A parametrized nonlinear predictive control strategy for relaxing COVID-19 social distancing measures in Brazil
title_short A parametrized nonlinear predictive control strategy for relaxing COVID-19 social distancing measures in Brazil
title_sort parametrized nonlinear predictive control strategy for relaxing covid-19 social distancing measures in brazil
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834916/
https://www.ncbi.nlm.nih.gov/pubmed/33309260
http://dx.doi.org/10.1016/j.isatra.2020.12.012
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