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MicroRNA-6862 inhibition elevates sphingosine kinase 1 and protects neuronal cells from MPP(+)-induced apoptosis

MPP(+) (1-methyl-4-phenylpyridinium)-induced dopaminergic neuronal cell apoptosis is associated with sphingosine kinase 1 (SphK1) inhibition. We here tested the potential effect of microRNA-6862 (miR-6862), a novel SphK1-targeting miRNA, on MPP(+)-induced cytotoxicity in neuronal cells. MiR-6862 loc...

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Detalles Bibliográficos
Autores principales:	Xue, Gang, Chen, Ju-ping, Li, Ya, Zhang, Zhi-qing, Zhu, Jian-liang, Dong, Wanli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834988/ https://www.ncbi.nlm.nih.gov/pubmed/33414358 http://dx.doi.org/10.18632/aging.202335

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