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Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans

Aging impairs the IGF-I signaling of bone marrow mesenchymal stem cells (bmMSCs), but the mechanism is unclear. Here, we found that the ability to auto-phosphorylate IGF-I receptor (IGF-IR) in response to IGF-I was decreased in the bmMSCs of aged donors. Conversely, data showed that decorin (DCN) ex...

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Detalles Bibliográficos
Autores principales:	Wong, Tze-Hong, Chen, Ting-Yu, Tseng, Kuo-Yun, Chen, Zih-Ying, Chen, Chung-Hsing, Lin, Feng-Huei, Wu, Hung-Ming, Lin, Shankung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835024/ https://www.ncbi.nlm.nih.gov/pubmed/33257596 http://dx.doi.org/10.18632/aging.202166

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