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Myocardial creep-induced misalignment artifacts in PET/MR myocardial perfusion imaging

PURPOSE: Misalignment between positron emission tomography (PET) datasets and attenuation correction (AC) maps is a potential source of artifacts in myocardial perfusion imaging (MPI). We assessed the impact of adenosine on the alignment of AC maps derived from magnetic resonance (MR) and PET datase...

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Autores principales: von Felten, Elia, Benetos, Georgios, Patriki, Dimitri, Benz, Dominik C., Rampidis, Georgios P., Giannopoulos, Andreas A., Bakula, Adam, Gräni, Christoph, Pazhenkottil, Aju P., Gebhard, Catherine, Fuchs, Tobias A., Kaufmann, Philipp A., Buechel, Ronny R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835156/
https://www.ncbi.nlm.nih.gov/pubmed/32681446
http://dx.doi.org/10.1007/s00259-020-04956-y
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author von Felten, Elia
Benetos, Georgios
Patriki, Dimitri
Benz, Dominik C.
Rampidis, Georgios P.
Giannopoulos, Andreas A.
Bakula, Adam
Gräni, Christoph
Pazhenkottil, Aju P.
Gebhard, Catherine
Fuchs, Tobias A.
Kaufmann, Philipp A.
Buechel, Ronny R.
author_facet von Felten, Elia
Benetos, Georgios
Patriki, Dimitri
Benz, Dominik C.
Rampidis, Georgios P.
Giannopoulos, Andreas A.
Bakula, Adam
Gräni, Christoph
Pazhenkottil, Aju P.
Gebhard, Catherine
Fuchs, Tobias A.
Kaufmann, Philipp A.
Buechel, Ronny R.
author_sort von Felten, Elia
collection PubMed
description PURPOSE: Misalignment between positron emission tomography (PET) datasets and attenuation correction (AC) maps is a potential source of artifacts in myocardial perfusion imaging (MPI). We assessed the impact of adenosine on the alignment of AC maps derived from magnetic resonance (MR) and PET datasets during MPI on a hybrid PET/MR scanner. METHODS: Twenty-eight volunteers underwent adenosine stress and rest 13N-ammonia MPI on a PET/MR. We acquired Dixon sequences for the creation of MRAC maps. After reconstruction of the original non-shifted PET images, we examined MRAC and PET datasets for cardiac spatial misalignment and, if necessary, reconstructed a second set of shifted PET images after manually adjusting co-registration. Summed rest, stress, and difference scores (SRS, SSS, and SDS) were compared between shifted and non-shifted PET images. Additionally, we measured the amount of cranial movement of the heart (i.e., myocardial creep) after termination of adenosine infusion. RESULTS: Realignment was necessary for 25 (89.3%) stress and 12 (42.9%) rest PET datasets. Median SRS, SSS, and SDS of the non-shifted images were 6 (IQR = 4–7), 12 (IQR = 7–18), and 8 (IQR = 2–11), respectively, and of the shifted images 2 (IQR = 1–6), 4 (IQR = 7–18), and 1 (IQR = 0–2), respectively. All three scores were significantly higher in non-shifted versus shifted images (all p < 0.05). The difference in SDS correlated moderately but significantly with the amount of myocardial creep (r = 0.541, p = 0.005). CONCLUSION: Misalignment of MRAC and PET datasets commonly occurs during adenosine stress MPI on a hybrid PET/MR device, potentially leading to an increase in false-positive findings. Our results suggest that myocardial creep may substantially account for this and prompt for a careful review and correction of PET/MRAC data.
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spelling pubmed-78351562021-01-29 Myocardial creep-induced misalignment artifacts in PET/MR myocardial perfusion imaging von Felten, Elia Benetos, Georgios Patriki, Dimitri Benz, Dominik C. Rampidis, Georgios P. Giannopoulos, Andreas A. Bakula, Adam Gräni, Christoph Pazhenkottil, Aju P. Gebhard, Catherine Fuchs, Tobias A. Kaufmann, Philipp A. Buechel, Ronny R. Eur J Nucl Med Mol Imaging Original Article PURPOSE: Misalignment between positron emission tomography (PET) datasets and attenuation correction (AC) maps is a potential source of artifacts in myocardial perfusion imaging (MPI). We assessed the impact of adenosine on the alignment of AC maps derived from magnetic resonance (MR) and PET datasets during MPI on a hybrid PET/MR scanner. METHODS: Twenty-eight volunteers underwent adenosine stress and rest 13N-ammonia MPI on a PET/MR. We acquired Dixon sequences for the creation of MRAC maps. After reconstruction of the original non-shifted PET images, we examined MRAC and PET datasets for cardiac spatial misalignment and, if necessary, reconstructed a second set of shifted PET images after manually adjusting co-registration. Summed rest, stress, and difference scores (SRS, SSS, and SDS) were compared between shifted and non-shifted PET images. Additionally, we measured the amount of cranial movement of the heart (i.e., myocardial creep) after termination of adenosine infusion. RESULTS: Realignment was necessary for 25 (89.3%) stress and 12 (42.9%) rest PET datasets. Median SRS, SSS, and SDS of the non-shifted images were 6 (IQR = 4–7), 12 (IQR = 7–18), and 8 (IQR = 2–11), respectively, and of the shifted images 2 (IQR = 1–6), 4 (IQR = 7–18), and 1 (IQR = 0–2), respectively. All three scores were significantly higher in non-shifted versus shifted images (all p < 0.05). The difference in SDS correlated moderately but significantly with the amount of myocardial creep (r = 0.541, p = 0.005). CONCLUSION: Misalignment of MRAC and PET datasets commonly occurs during adenosine stress MPI on a hybrid PET/MR device, potentially leading to an increase in false-positive findings. Our results suggest that myocardial creep may substantially account for this and prompt for a careful review and correction of PET/MRAC data. Springer Berlin Heidelberg 2020-07-18 2021 /pmc/articles/PMC7835156/ /pubmed/32681446 http://dx.doi.org/10.1007/s00259-020-04956-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
von Felten, Elia
Benetos, Georgios
Patriki, Dimitri
Benz, Dominik C.
Rampidis, Georgios P.
Giannopoulos, Andreas A.
Bakula, Adam
Gräni, Christoph
Pazhenkottil, Aju P.
Gebhard, Catherine
Fuchs, Tobias A.
Kaufmann, Philipp A.
Buechel, Ronny R.
Myocardial creep-induced misalignment artifacts in PET/MR myocardial perfusion imaging
title Myocardial creep-induced misalignment artifacts in PET/MR myocardial perfusion imaging
title_full Myocardial creep-induced misalignment artifacts in PET/MR myocardial perfusion imaging
title_fullStr Myocardial creep-induced misalignment artifacts in PET/MR myocardial perfusion imaging
title_full_unstemmed Myocardial creep-induced misalignment artifacts in PET/MR myocardial perfusion imaging
title_short Myocardial creep-induced misalignment artifacts in PET/MR myocardial perfusion imaging
title_sort myocardial creep-induced misalignment artifacts in pet/mr myocardial perfusion imaging
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835156/
https://www.ncbi.nlm.nih.gov/pubmed/32681446
http://dx.doi.org/10.1007/s00259-020-04956-y
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